ArticleRadiology case reports2026
A misdiagnosed case of tumefactive demyelinating lesion mimicking glioma: Imaging pitfalls and diagnostic lessons.
Article in Radiology case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Distinguishing cerebral glioma from tumefactive demyelinating lesion (TDL) remains a significant diagnostic challenge due to overlapping neuroimaging features despite vastly different management and prognoses. We present a case of a 51-year-old woman whose initial brain magnetic resonance imaging (MRI) was interpreted as suggestive of glioma. The patient declined surgical intervention. Follow-up MRI performed 3 months later demonstrated marked lesion reduction, supporting a demyelinating etiology. This case analyzes the factors contributing to the initial misdiagnosis, highlighting the critical role of imaging discriminators, such as the open-ring enhancement pattern, magnetic resonance spectroscopy (MRS), and perfusion-weighted imaging (PWI), as well as the value of systematic clinical reasoning in avoiding unnecessary surgical procedures.
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