Evidence map›Paper›PMID 41732531›Full record

ArticleRadiology case reports2026

Spontaneous myocardial injury in hypertrophic cardiomyopathy: Coexistence of microvascular dysfunction and microvascular obstruction.

Maethas Panyawongkhanti, Nonthikorn Theerasuwipakorn, Apichai Khongphatthanayothin, Pairoj Chattranukulchai

Abstract readCase Reports
In one paragraph

Article in Radiology case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Maethas PanyawongkhantiDivision of Cardiovascular Medicine, Department of Medicine, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Bangkok 10330, Thailand.
Nonthikorn TheerasuwipakornDivision of Cardiovascular Medicine, Department of Medicine, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Bangkok 10330, Thailand.
Apichai KhongphatthanayothinDepartment of Medicine, Center of Excellence in Arrhythmia Research, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand.
Pairoj ChattranukulchaiDivision of Cardiovascular Medicine, Department of Medicine, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Bangkok 10330, Thailand.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hypertrophic cardiomyopathy (HCM) is a genetic disorder characterized by left ventricular hypertrophy without abnormal loading conditions, often complicated by microvascular dysfunction (MVD), which leads to myocardial ischemia. While MVD in HCM has been extensively described, reports of concomitant microvascular obstruction (MVO) as a feature of spontaneous myocardial injury are scarce. We present a 58-year-old man with genetically confirmed HCM who experienced recurrent chest discomfort attributed to spontaneous myocardial injury. This was evidenced by markedly elevated biomarkers and cardiac magnetic resonance imaging (CMR) findings, including severe inducible myocardial ischemia on stress perfusion, myocardial edema, and MVO. This case highlights the potential coexistence of MVD and MVO in severe HCM, suggesting a complex interplay that may contribute to disease progression. Advanced imaging techniques, particularly CMR, are crucial in detecting myocardial damage and guiding management. Future research should explore the clinical significance of MVO in HCM and its potential as a therapeutic target.

Indexed as

Cardiac magnetic resonance imagingHypertrophic cardiomyopathyMicrovascular dysfunctionMicrovascular obstruction

Identifiers

PMID41732531
PMCPMC12925444

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.