Evidence map›Paper›PMID 41732488›Full record

ArticleiScience2026

Compartment-specific tumor-infiltrating immune cells and prognosis in breast cancer.

Aaron J Bernstein, Renske Keeman, Amber N Hurson, Fiona M Blows, Manjeet K Bolla, Jodi L Miller, Roger L Milne, Hugo Horlings, Alexandra J van den Broek, Clara Bodelon and 55 more

Abstract read
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

65 authors.

Aaron J BernsteinOffice of Drug Development Partnership Programs, National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD, USA.
Renske KeemanDivision of Molecular Pathology, Netherlands Cancer Institute, Amsterdam, the Netherlands.
Amber N HursonDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Fiona M BlowsDepartment of Oncology, University of Cambridge, Cambridge, UK.
Manjeet K BollaDepartment of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Jodi L MillerHistopathology/ISH Core Facility, CRUK Cambridge Institute, Cambridge, UK.
Roger L MilneCancer Epidemiology Division, Cancer Council Victoria, Melbourne, VIC, Australia.
Hugo HorlingsDepartment of Pathology, Netherlands Cancer Institute, Amsterdam, the Netherlands.
Alexandra J van den BroekDivision of Molecular Pathology, Netherlands Cancer Institute, Amsterdam, the Netherlands.
Clara BodelonDepartment of Population Sciences, American Cancer Society, Atlanta, GA, USA.
James M HodgeDepartment of Population Sciences, American Cancer Society, Atlanta, GA, USA.
Alpa V PatelDepartment of Population Sciences, American Cancer Society, Atlanta, GA, USA.
Lauren R TerasDepartment of Population Sciences, American Cancer Society, Atlanta, GA, USA.
Federico CanzianGerman Cancer Research Center (DKFZ), Heidelberg, Germany.
Rudolf KaaksGerman Cancer Research Center (DKFZ), Heidelberg, Germany.
Hermann BrennerGerman Cancer Research Center (DKFZ), Heidelberg, Germany.
Ben SchöttkerDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Sabine BehrensGerman Cancer Research Center (DKFZ), Heidelberg, Germany.
Jenny Chang-ClaudeGerman Cancer Research Center (DKFZ), Heidelberg, Germany.
Tabea MaurerCenter for Psychosocial Medicine, Department of Medical Psychology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Nadia ObiInstitute for Occupational and Maritime Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Fergus J CouchDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
H Raza AliCancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK.
Carlos CaldasDepartment of Clinical Biochemistry and Institute for Metabolic Science, School of Clinical Medicine, University of Cambridge, Cambridge, UK.
Irene AndrulisLunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada.
Gord GlendonLunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada.
Anna Marie MulliganDepartment of Laboratory Medicine and Pathobiology, University Health Network, University of Toronto, Toronto, ON, Canada.
Wilma MeskerLeiden University Medical Centre, Leiden, the Netherlands.
Agnes JagerDepartment of Medical Oncology, Erasmus Medical Centre Cancer Institute, Rotterdam, the Netherlands.
Annette Heemskerk-GerritsenDepartment of Medical Oncology, Erasmus Medical Centre Cancer Institute, Rotterdam, the Netherlands.
Peter DevileeLeiden University Medical Centre, Leiden, the Netherlands.
Scott M LawrenceCancer Genomics Research Laboratory, Frederick National Laboratory for Cancer Research, Rockville, MD, USA.
Jolanta LissowskaCentrum Onkologii-Instytut im. Marii Skłodowskiej-Curie, Warsaw, Poland.
Karun MutrejaCancer Genomics Research Laboratory, Frederick National Laboratory for Cancer Research, Rockville, MD, USA.
Thomas AhearnDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Stephen ChanockDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Maire A DugganDepartment of Pathology and Laboratory Medicine, University of Calgary, Calgary, Alberta, Canada.
Diana EcclesUniversity of Southampton, Southampton, UK.
J Louise JonesBarts Cancer Institute, Queen Mary University of London, London, UK.
Will TapperUniversity of Southampton, Southampton, UK.
Antoinette HollestelleDepartment of Medical Oncology, Erasmus Medical Centre Cancer Institute, Rotterdam, the Netherlands.
Maartje HooningDepartment of Medical Oncology, Erasmus Medical Centre Cancer Institute, Rotterdam, the Netherlands.
John MartensDeptartment of Medical Oncology, Erasmus Medical Centre Cancer Institute, Rotterdam, the Netherlands.
Carolien H M van DeurzenDepartment of Pathology, Erasmus Medical Centre Cancer Institute, Rotterdam, the Netherlands.
Angela CoxUniversity of Sheffield, Sheffield, UK.
Simon S CrossUniversity of Sheffield, Sheffield, UK.
Mikael HartmanDepartment of Surgery, Yong Loo Lin School of Medicine, National University of Singapore and National University Health Systems, Singapore, Republic or Singapore.
Jingmei LiGenome Institute of Singapore (GIS), Agency for Science Technology and Research (A∗STAR), Singapore, Republic of Singapore.
Thomas C PuttiNational University of Singapore, Singapore, Republic of Singapore.
Ute HamannMolecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Muhammad RashidMolecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Ania JakubowskaIndependent Laboratory of Molecular Biology and Genetic Diagnostics, Pomeranian Medical University in Szczecin, Szczecin, Poland.
Nicki CampHuntsman Cancer Institute and Department of Internal Medicine, University of Utah, Salt Lake City, UT, USA.
Melissa H CessnaDepartment of Pathology and Intermountain Biorepository, Intermountain Heath, Salt Lake City, UT, USA.
Amy Berrington de GonzalezInstitute of Cancer Research, London, UK.
Katarzyna BialkowskaDepartment of Genetics and Pathology, Pomeranian Medical University in Szczecin, Szczecin, Poland.
Jacek GronwaldDepartment of Genetics and Pathology, Pomeranian Medical University in Szczecin, Szczecin, Poland.
Jan LubińskiDepartment of Genetics and Pathology, Pomeranian Medical University in Szczecin, Szczecin, Poland.
Siddhartha YadavDepartment of Oncology, Mayo Clinic, Rochester, MN, USA.
Pietro LioDepartment of Computer Science and Technology, University of Cambridge, Cambridge, UK.
Douglas F EastonDepartment of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Mustapha AbubakarDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Montse Garcia-ClosasInstitute of Cancer Research, London, UK.
Paul D P PharoahDepartment of Computational Biology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Marjanka K SchmidtNetherlands Cancer Institute, Amsterdam, the Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Breast cancer immune response is important to patient outcome, but the prognostic interaction between tissue-infiltrating immune cell (TIIC) types is not well-characterized. We evaluated the associations between CD8

Indexed as

Artificial intelligenceImmunologyOncology

Identifiers

PMID41732488
PMCPMC12925133

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.