ArticleiScience2026
Radiomics predicts poorly differentiated hepatocellular carcinoma and uncovers ribosomal-immune dysregulation mechanism.
Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Exploring the mechanism by which triphenyl phosphate promotes malignant phenotypes in bladder and kidney cancer through MMP9 based on bioinformatics analysis and experimental validation.Clinical and experimental medicine · 2026Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hepatocellular carcinoma (HCC) shows marked spatial heterogeneity, limiting biopsy-based Edmondson-Steiner (ES) grading. We developed a multicenter radiogenomic framework to noninvasively predict ES grade and explore underlying molecular mechanisms. Arterial-phase DCE-MRI from 295 patients and The Cancer Imaging Archive (TCIA) cases were analyzed using three tumor regions (body, edge, and out). An integrated volume-of-interest (VOI) random forest (RF) model was trained with selected features and externally validated. Radiogenomic analysis correlated radscore with TCIA transcriptomic profiles using weighted gene co-expression network analysis (WGCNA). The model achieved high discrimination (area under the curve [AUC] 0.959 internally; 0.860 externally). Radscore-associated modules revealed ribosomal dysregulation and immune exhaustion. A derived prognostic signature stratified and The Cancer Genome Atlas (TCGA) patients into distinct risk groups and independently predicted survival (hazard ratio [HR] 3.95,
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Registered trials
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