ArticleTherapeutic advances in urology
A clinical entity of multiple ureteral fibroepithelial polyps with annular stenosis and tortuosity: clinical features and management considerations.
Article in Therapeutic advances in urology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Ureteral fibroepithelial polyps (FEPs) are rare. The management of multiple polyps presents unique challenges, particularly when combined with other variants. These complex cases warrant individualized surgical planning. Objective: To characterize a distinct subset of complex ureteral FEPs defined by the triad of multiple annular stenosis, tortuous ureter, and multiple polyps-collectively termed "MASTUMP," and to investigate its clinical, pathological, genetic features, and management considerations. Design: Single-center retrospective study. Methods: This study included nine patients treated for complex ureteral polyps between December 2019 and October 2024. Inclusion criteria required the presence of multiple FEPs (⩾3), ureteral tortuosity, and annular stenosis (⩾50% luminal narrowing). Clinical characteristics, imaging findings, surgical details, histopathology, and whole-exome sequencing (WES) were collected. Surgical outcomes and follow-up data were analyzed. Results: The cohort (77.7% male, mean age 35.1 ± 13.1 years) presented with bilateral (55.5%) or left-sided (44.4%) polyps, with a median lesion length of 4 (range 1-6) cm. All patients had a history of failed endoscopic or surgical management. According to the society of fetal urology grading system, hydronephrosis was classified as grade 1 in one case, grade 2 in three cases, grade 3 in four cases, and grade 4 in one case, with a mean anterior posterior diameter of 2.43 ± 0.88 cm. WES identified mutations in NRIP1 and TSC2 in two patients. Surgical management included segmental ureterectomy with reconstruction via ureteroureterostomy (two cases), pelvic flap (one case), lingual mucosal graft (one cases), and ileal ureter replacement (five cases). Over a median follow-up of 46.3 (range 11.5-75.4) months, no recurrences were observed. Conclusion: MASTUMP syndrome represents a clinical entity within complex ureteral polyps, potentially associated with congenital anomalies of the kidney and urinary tract. Endoscopic treatment carries a high risk of recurrence and should be approached with caution. Surgical resection with individualized reconstructive strategies offers durable outcomes. Further genetic studies and multicenter validation are essential to refine diagnostic criteria and treatment strategies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.