Evidence map›Paper›PMID 41732411›Full record

ArticleBrain & spine2026

Spinal cord protection by epidural separation during vertebral cryoablation for metastatic spine disease: A proof-of-concept preclinical study.

Takaaki Uto, Satoshi Kato, Noriaki Yokogawa, Takaki Shimizu, Motoya Kobayashi, Satoshi Nagatani, Masafumi Kawai, Yuji Ishino, Kazuhiro Nanpo, Megumu Kawai and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain & spine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Takaaki UtoDepartment of Orthopedic Surgery, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Ishikawa, Japan.
Satoshi KatoDepartment of Orthopedic Surgery, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Ishikawa, Japan.
Noriaki YokogawaDepartment of Orthopedic Surgery, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Ishikawa, Japan.
Takaki ShimizuDepartment of Orthopedic Surgery, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Ishikawa, Japan.
Motoya KobayashiDepartment of Orthopedic Surgery, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Ishikawa, Japan.
Satoshi NagataniDepartment of Orthopedic Surgery, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Ishikawa, Japan.
Masafumi KawaiDepartment of Orthopedic Surgery, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Ishikawa, Japan.
Yuji IshinoDepartment of Orthopedic Surgery, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Ishikawa, Japan.
Kazuhiro NanpoDepartment of Orthopedic Surgery, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Ishikawa, Japan.
Megumu KawaiDepartment of Orthopedic Surgery, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Ishikawa, Japan.
Satoru DemuraDepartment of Orthopedic Surgery, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Ishikawa, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Cryoablation for spinal metastases is limited by the risk of cryogenic neural injury near the spinal cord. Physical separation between the vertebral body and dura may provide a thermal margin, but the distance-temperature relationship in the epidural space remains insufficiently defined. Research question: This exploratory study aimed to map the association between surgically created epidural separation distance and local thermal and neurophysiological changes during vertebral cryoablation in a canine model. Material and methods: In a non-randomized, unblinded, two-phase pilot study, we first performed Results: Discussion and conclusion: In this proof-of-concept canine study, epidural separation distance was associated with ventral epidural temperature and short-term CMAP recovery during vertebral cryoablation. These findings do not establish a clinical safety threshold and require validation in clinically relevant models, including studies with survival and histologic assessment.

Indexed as

Animal modelCryoablationEpidural separationSpinal cord injurySpinal metastases

Identifiers

PMID41732411
PMCPMC12925502

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.