ArticleHeart rhythm O22026
Local modifications in tissular conditions before PFA increases acute lesion size.
Article in Heart rhythm O2, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
Background: Pulsed field ablation (PFA) is a novel nonthermal cardiac ablation technology based on irreversible electroporation. Although calcium-enhanced electroporation to treat solid tumors has proved successful, the applicability of this technique to create deeper lesions in the left ventricle remains unknown. Objective: This study aimed to determine whether changes in local tissular conditions may have an impact on lesion formation in PFA. Methods: 5 anesthetized pigs received local epicardial injections of 200 mM calcium chloride (CaCl Results: We performed 31 ablations (21 CaCl Conclusion: In this proof-of-concept study, we show for the first time that changes in local tissular conditions may have an impact on lesion formation in PFA. The combination of calcium injection and PFA induced ventricular fibrillation in half of the applications.
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