Evidence map›Paper›PMID 41732238›Full record

ArticleHeart rhythm O22026

Using subcutaneous nerve stimulation to control atrial fibrillation.

Peng-Sheng Chen, Xiao Liu, Tiffany G Perry, Robert J Siegel, Alexander Tuchman, Anxhela Kote, Jewel N Reaso, Kathleen A Lane, Carine Rosenberg, K Taiga Andersson and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heart rhythm O2, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Peng-Sheng ChenDepartment of Cardiology, Smidt Heart Institute, Cedars-Sinai Health Sciences University, Los Angeles, California.
Xiao LiuDepartment of Cardiology, Smidt Heart Institute, Cedars-Sinai Health Sciences University, Los Angeles, California.
Tiffany G PerryDepartment of Neurosurgery, Cedars-Sinai Health Sciences University, Los Angeles, California.
Robert J SiegelDepartment of Cardiology, Smidt Heart Institute, Cedars-Sinai Health Sciences University, Los Angeles, California.
Alexander TuchmanDepartment of Neurosurgery, Cedars-Sinai Health Sciences University, Los Angeles, California.
Anxhela KoteDepartment of Cardiology, Smidt Heart Institute, Cedars-Sinai Health Sciences University, Los Angeles, California.
Jewel N ReasoDepartment of Cardiology, Smidt Heart Institute, Cedars-Sinai Health Sciences University, Los Angeles, California.
Kathleen A LaneDepartment of Biostatistics and Health Data Science, Indiana University School of Medicine, Indianapolis, Indiana.
Carine RosenbergDepartment of Cardiology, Smidt Heart Institute, Cedars-Sinai Health Sciences University, Los Angeles, California.
K Taiga AnderssonDepartment of Cardiology, Smidt Heart Institute, Cedars-Sinai Health Sciences University, Los Angeles, California.
Susan StrakaDepartment of Cardiology, Smidt Heart Institute, Cedars-Sinai Health Sciences University, Los Angeles, California.
Lan S ChenDepartment of Cardiology, Smidt Heart Institute, Cedars-Sinai Health Sciences University, Los Angeles, California.
Thomas H EverettDivision of Cardiovascular Medicine, Krannert Cardiovascular Research Center, School of Medicine, Indiana University, Indianapolis, Indiana.
Michael M ShehataDepartment of Cardiology, Smidt Heart Institute, Cedars-Sinai Health Sciences University, Los Angeles, California.
Ashkan EhdaieDepartment of Cardiology, Smidt Heart Institute, Cedars-Sinai Health Sciences University, Los Angeles, California.
Xunzhang WangDepartment of Cardiology, Smidt Heart Institute, Cedars-Sinai Health Sciences University, Los Angeles, California.
Eugenio CingolaniDepartment of Cardiology, Smidt Heart Institute, Cedars-Sinai Health Sciences University, Los Angeles, California.
Archana RamireddyDepartment of Cardiology, Smidt Heart Institute, Cedars-Sinai Health Sciences University, Los Angeles, California.
Eric D BraunsteinDepartment of Cardiology, Smidt Heart Institute, Cedars-Sinai Health Sciences University, Los Angeles, California.
Xiaochun LiDepartment of Biostatistics and Health Data Science, Indiana University School of Medicine, Indianapolis, Indiana.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Subcutaneous nerve stimulation (ScNS) can reduce atrial arrhythmia in canine models. Objective: This study aimed to test the hypothesis that ScNS can reduce the burden of paroxysmal atrial fibrillation (AF) by a randomized, sham-controlled clinical trial. Methods: Patients with drug-resistant symptomatic paroxysmal AF were randomized to receive ScNS (10 Hz, 3.5 mA output, 20 s on, and 1 min off) for 2 weeks. The AF burden was determined by ePatch recordings. Results: Of the 46 patients who consented, 12 patients (8 men and 4 women, 60.9 ± 10.2 years) were randomized. The change in AF burden at week 1 from eligibility week was not significantly different between the groups ( Conclusion: 2 weeks of ScNS did not reduce the AF burden or control the VR in patients with paroxysmal AF. However, there was a slower increase in %AF burden over time in the Stimulation Group than in the Sham Group.

Indexed as

Apple WatchAtrial fibrillation burdenInvestigational device exemptionQuality-of-lifeSkin sympathetic nerve activity

Identifiers

PMID41732238
PMCPMC12925772

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.