SynthesisEquine veterinary journal2026
Clinical and research applications of synthetic bone substitutes in equine veterinary medicine: A systematic review.
Synthesis in Equine veterinary journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
backgroundBone grafting in equine medicine offers a promising contribution to treating orthopaedic developmental diseases and chondral, osteochondral and segmental bone defects. Among grafts, synthetic bone substitutes-alloplastics-show favourable biological properties addressing numerous limitations presented by autografts, xenografts and allografts.
objectivesTo compile and disseminate clinical data and research findings from existing publications on the use of alloplastics in horses. STUDY
designSystematic review.
methodsFollowing Preferred Reporting Items for Systematic Reviews and Meta-analysis 2020 guidelines, literature searches were conducted in PUBMED, Scopus and Web of Knowledge. The inclusion criteria covered case reports and research articles on the use of alloplastics in the horses. The selected research articles were grouped considering clinical and experimental studies. A risk of bias assessment was performed for the research articles.
resultsUse of synthetic bone substitutes in horses has been described in 17 publications to date, grouped as 5 case reports and 12 research articles. The latter were subdivided by main study issue-as involved subchondral cystic lesion, aneurysmal bone cyst and chondral, osteochondral or segmental bone defects. The four treatment models were distinguished and described. MAIN LIMITATIONS: The lack of clinical and alloplastics data in some records. Clinical evaluation in some studies was inconsistent or incomplete. A risk of bias particularly arises from missing data, outcome measurement and the reported results.
conclusionsIn equine medicine, hydroxyapatite, calcium phosphate and β-tricalcium phosphate were the leading alloplastics applied. When applied alone, they demonstrated osteoconductive and osteoinductive properties, while the addition of biologically active additives-especially autologous bone marrow-enhanced these biological properties toward osteogenic and chondrogenic effects. Treatment outcomes were generally favourable, although segmental bone defect treatment requires considering the limitations associated with weight-bearing effects. These findings suggest alloplastics in horses may be particularly beneficial for treating certain bone diseases.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.