ArticleFuture oncology (London, England)2026
Real-world outcomes after CAR T versus standard therapy in third-line or later relapsed or refractory follicular lymphoma in the United States.
Article in Future oncology (London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundRelapsed/refractory (R/R) follicular lymphoma (FL) often requires multiple lines of therapy.
objectiveTo compare time to next treatment (TTNT), treatment-free interval (TFI), healthcare resource utilization (HRU), and downstream costs among R/R FL patients treated with CAR T versus non-CAR T therapy.
methodsAdult R/R FL patients with ≥2 prior lines of therapy were stratified into CAR T and non-CAR T cohorts. The Index Date was CAR T infusion (CAR T) or 3L initiation (non-CAR T). Outcomes included TTNT, TFI, HRU, and costs. Analyses were descriptive, incorporating Kaplan-Meier methods and multivariable models.
results335 CAR T and 4,342 non-CAR T patients were included. Median TTNT was not reached for CAR T, with longer TFIs observed in descriptive analyses. Adjusted analyses showed lower pharmacy costs at both 3L+ (CR 0.32; 95% CI 0.21-0.48;
conclusionsIn this real-world analysis, CAR T was associated with longer TTNT, longer TFI, and lower downstream FL-related costs compared with non-CAR T therapy, with interpretation informed by differences in follow-up time and treatment context.
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