Evidence map›Paper›PMID 41732038›Full record

ArticleSmall (Weinheim an der Bergstrasse, Germany)2026

High Sensitivity Cardiac Troponin I Detection via MP-Locked Aptamer and Multimeric DNAzyme-Coupled Hyperbranched Hybridization Chain Reaction.

Sayantan Tripathy, Sahil Sharma, Ng Ka Wai, Siddhant Jaitpal, Anthony Dongchau, Saugat Bhattacharyya, Sonya R Wesselowski, Ashley B Saunders, Gerard L Coté, Samuel B Mabbott

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Small (Weinheim an der Bergstrasse, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sayantan TripathyDepartment of Biomedical Engineering, Texas A&M University, College Station, Texas, USA.ORCID https://orcid.org/0000-0002-9536-5947
Sahil SharmaSchool of Computing, Engineering and Intelligent Systems, Ulster University, Londonderry, Northern Ireland, UK.
Ng Ka WaiDepartment of Biomedical Engineering, Texas A&M University, College Station, Texas, USA.
Siddhant JaitpalDepartment of Biomedical Engineering, Texas A&M University, College Station, Texas, USA.
Anthony DongchauDepartment of Biomedical Engineering, Texas A&M University, College Station, Texas, USA.
Saugat BhattacharyyaSchool of Computing, Engineering and Intelligent Systems, Ulster University, Londonderry, Northern Ireland, UK.
Sonya R WesselowskiDepartment of Small Animal Clinical Sciences, College of Veterinary Medicine & Biomedical Sciences, Texas A&M University, College Station, Texas, USA.
Ashley B SaundersDepartment of Small Animal Clinical Sciences, College of Veterinary Medicine & Biomedical Sciences, Texas A&M University, College Station, Texas, USA.
Gerard L CotéDepartment of Biomedical Engineering, Texas A&M University, College Station, Texas, USA.
Samuel B MabbottDepartment of Biomedical Engineering, Texas A&M University, College Station, Texas, USA.ORCID https://orcid.org/0000-0003-4926-5467

Funding

National Science Foundation 1648451United States-Ireland-Northern Ireland R&D Partnership supplement
6 · The paper itself

Abstract

Timely and sensitive detection of cardiac troponin I (cTnI) is critical for early diagnosis of myocardial infarction, particularly at the point-of-care. Herein, we present a novel colorimetric biosensing platform for high-sensitivity detection of cardiac troponin I (cTnI). The platform integrates magnetic particle (MP) anchored locked aptamers, stabilized by short complementary strands to minimize nonspecific folding and background activation prior to target binding, with hyperbranched hybridization chain reaction (HCR) and catalytic DNA (DNAzyme) nanocomplex-mediated signal amplification. This enzyme-free amplification system detects cTnI directly in 25-30 min, with a calculated detection limit of 0.25 ng L

Indexed as

Aptamers, NucleotideDNA, CatalyticNucleic Acid HybridizationTroponin IAnimalsBiosensing TechniquesColorimetryDogsHumansAptamers, NucleotideDNA, CatalyticTroponin IDNAzymehyperbranched hybridization chain reactionlocked aptamermachine learningmyocardial infarction

Identifiers

PMID41732038
PMCPMC13054452

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.