Evidence map›Paper›PMID 41732015›Full record

ArticleImmunology and cell biology2026

The NF-κB transcription factor RelA directs mucosal-associated invariant T-cell development.

Thomas S Fulford, Hui-Fern Koay, Raelene Grumont, Darryl N Johnson, Sebastian Scheer, Hendrik J Nel, Ranjeny Thomas, Jeffrey Yw Mak, David P Fairlie, Charis E Teh and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunology and cell biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Thomas S FulfordDepartment of Microbiology & Immunology at the Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, VIC, Australia.ORCID https://orcid.org/0000-0002-7210-5739
Hui-Fern KoayDepartment of Microbiology & Immunology at the Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, VIC, Australia.
Raelene GrumontDepartment of Biochemistry and Molecular Biology, Biomolecular Discovery Institute, Monash University, Clayton, VIC, Australia.
Darryl N JohnsonDepartment of Microbiology & Immunology at the Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, VIC, Australia.
Sebastian ScheerDepartment of Biochemistry and Molecular Biology, Biomolecular Discovery Institute, Monash University, Clayton, VIC, Australia.ORCID https://orcid.org/0000-0002-9716-5009
Hendrik J NelFrazer Institute, University of Queensland, Woolloongabba, QLD, Australia.
Ranjeny ThomasFrazer Institute, University of Queensland, Woolloongabba, QLD, Australia.ORCID https://orcid.org/0000-0002-0518-8386
Jeffrey Yw MakInstitute for Molecular Bioscience, University of Queensland, Brisbane, QLD, Australia.
David P FairlieInstitute for Molecular Bioscience, University of Queensland, Brisbane, QLD, Australia.
Charis E TehThe Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.
Daniel Hd GrayThe Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.
Vanessa L BryantThe Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.
Colby ZaphDepartment of Biochemistry and Molecular Biology, Biomolecular Discovery Institute, Monash University, Clayton, VIC, Australia.
Lorraine A O'ReillyThe Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.
Steven GerondakisDepartment of Biochemistry and Molecular Biology, Biomolecular Discovery Institute, Monash University, Clayton, VIC, Australia.
Dale I GodfreyDepartment of Microbiology & Immunology at the Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, VIC, Australia.

Funding

Fonds National de la Recherche (FNR)National Health and Medical Research Council 1113293National Health and Medical Research Council 1117017National Health and Medical Research Council 1117766National Health and Medical Research Council 1121325National Health and Medical Research Council 1140126National Health and Medical Research Council 1158024National Health and Medical Research Council 1187367National Health and Medical Research Council 2008913National Health and Medical Research Council 2009551National Health and Medical Research Council 2029937Sir Clive McPherson Family Fellowshipthe Luxembourg National Research Fund and the Fondation Cancer, Luxembourg C22/BM/17041936
6 · The paper itself

Abstract

Mucosal-associated invariant T (MAIT) cells are characterized by rapid responses to nonpeptide antigens via invariant T-cell receptors (TCR), and expression of an "effector-like" T-cell phenotype. The transcription factor promyelocytic leukemia zinc finger (PLZF) is crucial for defining the function of MAIT cells and other unconventional T cells; however, the transcriptional programs that direct MAIT cell development are not fully elucidated. Here, we show that the canonical NF-κB transcription factor RelA is critical for MAIT cell thymic development, but not responsiveness to antigen, whereas NF-κB1 and c-Rel make more limited contributions. MAIT cell development is also impaired in the absence of the linear ubiquitin signaling complex (LUBAC), an upstream regulator of NF-κB signaling, implicating this pathway in establishing the MAIT cell pool. Collectively, these data suggest LUBAC and NF-κB signals as elements of the transcriptional network controlling MAIT cell development.

Indexed as

Cell DifferentiationMucosal-Associated Invariant T CellsTranscription Factor RelAAnimalsMiceSignal TransductionTranscription Factor RelAdevelopmentLUBACMAIT cellsNF‐κBRelA

Identifiers

PMID41732015
PMCPMC13071142

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.