SynthesisMedicine2026
Polymorphisms of long non-coding RNA HOTAIR and susceptibility to gastrointestinal cancers: A meta-analysis.
Synthesis in Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
backgroundThe long non-coding RNA HOTAIR has been implicated in tumor initiation and progression, and multiple case-control studies have explored whether common HOTAIR single-nucleotide polymorphisms influence susceptibility to gastrointestinal (digestive system) malignancies. However, published findings remain inconsistent across populations and cancer types.
methodsWe systematically searched PubMed, Embase, China National Knowledge Infrastructure, and Wanfang for eligible case-control studies evaluating associations between HOTAIR polymorphisms and digestive system cancer risk. Pooled odds ratios with 95% confidence intervals were calculated to estimate genetic effects. Between-study heterogeneity guided the use of fixed- or random-effects models. Prespecified subgroup analyses, sensitivity analyses, and publication-bias assessments were performed.
resultsA total of 25 studies comprising 12,521 cases and 14,610 controls were included. Overall evidence supported an association between digestive system cancer susceptibility and rs920778 (C>T) as well as rs4759314 (A>G), with signals persisting in several subgroup analyses. In contrast, rs7958904 (G>C) showed a risk-reducing pattern in the overall analysis and in colorectal cancer-focused comparisons. No convincing association was observed for rs1899663 (G>T) or rs874945 (G>A). Evidence for less frequently investigated loci (e.g., rs12826786 and rs17720428) was limited and warrants further validation.
conclusionsCurrent pooled data suggest that selected HOTAIR variants - particularly rs920778 and rs4759314 - may contribute to inherited susceptibility to digestive system cancers, whereas rs1899663 and rs874945 appear unrelated in available datasets. Larger, well-designed studies across diverse ancestries and cancer sites are needed to confirm these findings and clarify potential gene-environment interactions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.