ArticleMedicine2026
Associations between dietary habits and depressive disorder: A diet-wide Mendelian randomization study.
Article in Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dietary habits are associated with the onset and progression of major depressive disorder (MDD). Nevertheless, a direct association between diet and MDD remains unclear. Therefore, we used a two-sample Mendelian randomization (MR) method to systematically investigate causal relationships between dietary habits and MDD. We collected summary statistics for dietary habits based on publicly available genome-wide association data from the UK Biobank (n = 461,981) and summary statistics of data from the Psychiatric Genomics Consortium (n = 484,598). MR estimates from the genetic tools were combined using a weighted median method. To validate the robustness of the results, we compared the results of the weighted median with those of the inverse variance weighting, weighted mode, and MR-PRESSO. The results MDD was associated with 5 types of dietary habits, including salt added to food (odds ratio (OR): 1.0182, 95% confidence interval (CI): 0.0087-0.0273, P = .0001), beef intake (OR: 0.9395, 95% CI: -0.0964 to -0.0284, P = .0003), oily fish intake (OR: 1.0592, 95% CI: 0.0084-0.1065, P = .0252), bread intake (OR: 0.9313, 95% CI: -0.1366 to -0.0057, P = .0420), and alcohol intake frequency (OR: 1.0085, 95% CI: 0.0006-0.0163, P = .0341). The results suggest a causal relationship between dietary habits and MDD, identifying potential protective and risk factors. These results provide a new reference for the prevention of MDD via dietary regulation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.