ArticleMedicine2026
The impact of different intensities of physical activity on the risk of venous thromboembolism: A Mendelian randomization study.
Article in Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Venous thromboembolism (VTE) is a leading cause of cardiovascular disease, which seriously threatens human health. Physical activity (PA) has multiple benefits for health and well-being, while whether PA is associated with the risk of VTE remains debated. A 2-sample Mendelian randomization (MR) analysis was conducted to evaluate the causal relationship between different intensities of PA and the risk of VTE. Genetic instruments associated with PA were sourced from the UK Biobank, and VTE data came from the latest publicly released R10 data of the FinnGen study. The primary statistical method employed was the inverse variance weighted approach. MR-Egger regression, weighted median, and MR pleiotropy residual sum and outlier tests were then used to evaluate the robustness of the results. Data of 4,12,181 individuals with VTE from FinnGen and 13,35,561 participants with 3 intensities of PA from UK Biobank were obtained. Our study revealed a significant association between vigorous PA and a reduced risk of VTE (OR = 0.727, 95% CI = 0.576-0.920, P < .017). Regarding the impact of light and moderate PA on VTE risk, these associations did not achieve statistical significance (P > .017). However, at a relaxed significance level (0.017 < P < .05), the inverse variance weighted method identified suggestive evidence of an association between light PA and a reduced risk of VTE (OR = 0.778, 95% CI = 0.610-0.994, P = .045). This study revealed a significant association between vigorous PA and a reduced risk of VTE, providing constructive suggestions for VTE preventive and intervention strategies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.