SynthesisMedicine2026
The effect of moisturizers on acute radiation dermatitis: A systematic review and meta-analysis.
Synthesis in Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
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Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis systematic review and meta-analysis aims to evaluate the effectiveness of moisturizers in preventing acute radiation dermatitis (ARD) in patients undergoing radiotherapy (RT).
methodWe searched the PubMed, Cochrane Library, Embase, and Web of Science databases for literature from inception until August 26, 2025, identifying 13 randomized controlled trials that explored the impact of moisturizers on ARD. Statistical analyses were performed using RevMan 5.3 and STATA 15 software. The Cochrane risk of Bias tool (RoB 2.0) was used to evaluate the risk of bias in the included studies.
resultThe primary outcomes measured included the severity of ARD, and the secondary outcomes were skin-related quality of life, pruritus symptoms, and skin water content. From 1430 records screened, 13 studies were included investigating the effectiveness of moisturizers in patients undergoing RT. A total of 1203 patients with breast cancer or head and neck cancer were involved, including 603 patients in the intervention group and 600 patients in the control group. Results indicated that the probability of not developing ARD was higher in the moisturizer group compared to the control group (RR = 1.73, 95% CI [1.11-2.70], P = .02). The incidence of pruritus was lower in the moisturizer group than in the control group (RR = 0.69, 95% CI [0.53-0.90], P = .007), with a significantly lower probability of severe pruritus (≥ Grade 2) (RR = 0.06, 95% CI [0.01-0.67], P = .02). However, there were no statistically significant differences between the moisturizer and control groups regarding quality of life and water content.
conclusionCurrent evidence suggests that the use of moisturizers may have a positive effect on radiation dermatitis.
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