ArticleAnnals of African medicine2026
A High Dose of Short-term Intraperitoneal D-galactose-induced Aging Process in Male Rats.
Article in Annals of African medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
aimsIntraperitoneal injection of D-galactose (D-gal i.p.) can accelerate aging has been used to develop models of aging previously, long-term use of D-gal has been used to induce aging in mice. Researchers are trying to determine whether short-term administration of high doses of D-gal i.p. in rats is able to induce significant signs similar to natural aging, namely increased oxidative stress and myostatin.
methodsRats aged 6 months were induced D-gal i.p dose of 300 mg/mL/kg for 1 week. Biochemical analysis was performed for the estimation of systemic antioxidants and inflammation.
resultsShort-term administration of D-gal i.p significantly increased systemic inflammation and myostatin level. In the treatment group, there is an increased superoxide dismutase activity although lower compared with NaCl 0.9% i.p.
conclusionD-galactose intraperitoneally indeed accelerates aging in animal models by inducing oxidative stress and other aging-related biochemical changes, even with short-term high-dose administrations in one week.
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