ArticleJournal of Alzheimer's disease : JAD2026
Physical activity across the life course and neural biomarkers.
Article in Journal of Alzheimer's disease : JAD, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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9 authors.
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Abstract
BackgroundPhysical activity (PA) may decrease the risk of Alzheimer's disease and related disorders (ADRD), although most research has focused on exercise. In addition, ADRD prevention may be most effective when administered earlier in the life course, when changes in the brain may occur 20-25 years before the onset of symptoms. Finally, amyloid-β (A) and tau (T) accumulation are followed by neurodegeneration (N), key features of AD. However, there are additional biomarkers associated with ADRD. The association between different types of PA across the life course and biomarkers beyond the AT(N) framework is unknown.ObjectiveExamine the association between different types of PA across the life course and biomarkers beyond the AT(N) framework.MethodsPA (occupation/school, transportation, household) across the life course (school-age, adolescence, young adult, middle adult) was assessed. AD pathology, neurodegeneration, synaptic dysfunction, and gliosis were measured with the Roche NeuroToolKit, a panel of exploratory prototype assays for cerebrospinal fluid biomarkers. Significant bivariate correlations were followed by logistic regression.ResultsYoung adult occupation/school PA was a significant predictor of neurofilament light protein (NfL, OR = 0.969, 95% CI = 0.940-0.999); the full model was significant, χ
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