Evidence map›Paper›PMID 41731662›Full record

ArticleJournal of addiction medicine2026

Low-threshold Buprenorphine: Proposing the Ideal Service Model to Engage People With Severe Opioid Use Disorder.

Aaron D Fox, Sarah E Messmer, Benjamin T Hayes, Elizabeth Salisbury-Afshar, Avik Chatterjee, Andrea U Jakubowski

Abstract read
In one paragraph

Article in Journal of addiction medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sarah E Messmer
Benjamin T Hayes
Elizabeth Salisbury-Afshar
Avik Chatterjee
Andrea U Jakubowski

Funding

Microdosing initiation of buprenorphine for people seeking treatment for opioid use disorderK23DA055933 · NIDA · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI Benjamin T Hayes · 2022 to 2026
$971k
Examining injectable buprenorphine implementation strategies in low-threshold and primary care settingsK23DA052627 · NIDA · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI Andrea U Jakubowski · 2023 to 2026
$783k
Mentorship in research on opioid use disorder treatment and HIV preventionK24DA057873 · NIDA · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI Aaron D Fox · 2023 to 2026
$739k
NIDA NIH HHS K23 DA052627NIDA NIH HHS K23 DA055933NIDA NIH HHS K24 DA057873
6 · The paper itself

Abstract

Low-threshold buprenorphine treatment has been described as a general approach to office-based buprenorphine treatment that prioritizes access to care, flexibility, and patient-centeredness. Proposed principles have included same-day treatment entry, flexible policies and procedures, a harm reduction orientation, and availability in unconventional settings. This commentary, which summarizes critical insights from practitioners of low-threshold buprenorphine treatment, expands on these principles by describing clinical and social services that have been included in successful programs. Potential critiques of low-threshold buprenorphine treatment are also addressed. The main goal of the commentary is to describe the ideal components of low-threshold buprenorphine treatment that could inform the development, evaluation, and dissemination of these innovative programs.

Indexed as

buprenorphinehealth services accessibilitylow thresholdopioid use disorder

Identifiers

PMID41731662
PMCPMC13095200

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.