ReviewACS infectious diseases2026
Targeting of the Gram-Negative Outer Membrane for Antibiotic Discovery and Potentiation.
Review in ACS infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Novel Bacterial Topoisomerase Inhibitors: A New Front in an Old War.Journal of molecular biology · 2026Review
- Repurposing Ponatinib Hydrochloride as an Antibacterial and Antibiofilm Agent Against Multidrug-ResistantMicroorganisms · 2026Article
- TheInternational journal of molecular sciences · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The emergence of multidrug resistance underscores the urgent need to develop new classes of antibiotics with novel mechanisms of action. The majority of antibiotics currently in use are designed to target Gram-positive bacteria. However, Gram-negative bacteria can circumvent the effects of the majority of drug molecules due to the unique composition of their outer membrane. This additional layer functions as a formidable barrier, impeding the penetration of compounds into the cell. In this context, several strategies have been identified to facilitate the accumulation of compounds in Gram-negative bacteria. This review provides a concise overview of the physicochemical properties that can assist in the entry and accumulation of compounds in Gram-negative bacteria, and it also covers various approaches for targeting or circumventing the outer membrane-mediated barrier of Gram-negative pathogenic bacteria.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.