ArticleJournal of health, population, and nutrition2026
Dietary index for gut microbiota and DXA-derived visceral adiposity: a cross-sectional study.
Article in Journal of health, population, and nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundVisceral adipose tissue (VAT) is a critical cardiometabolic risk factor, yet the association between the dietary index for gut microbiota (DI-GM) and VAT mass remains unclear.
methodsThis cross-sectional study included 9,805 adults aged 20-59 years from the National Health and Nutrition Examination Survey (NHANES) 2011-2018 (age range based on DXA data availability). DI-GM scores were calculated based on 24-hour dietary recall data using 13 dietary components. VAT mass was directly measured using dual-energy X-ray absorptiometry (DXA). Multivariable weighted linear regression models, restricted cubic spline (RCS) analysis, and subgroup analyses were employed to assess the association between DI-GM and VAT mass.
resultsAfter comprehensive adjustment for potential confounders, DI-GM score was significantly inversely associated with VAT mass (β = -8.8, 95% CI: -12.0 to -5.5, P < 0.001). Participants in the highest DI-GM quartile (≥ 6 points) had 38.1 g lower VAT mass compared to those in the lowest quartile (0-3 points) (P < 0.001). RCS analysis revealed a linear dose-response relationship with no evidence of nonlinearity (P for nonlinearity = 0.632). Subgroup analyses revealed that this inverse association was more pronounced among individuals aged 40-59 years (β = -12.7, 95% CI: -18.3 to -7.1) and females (β = -12.0, 95% CI: -16.2 to -7.9), with significant interactions detected (P for interaction = 0.001 and 0.032, respectively).
conclusionHigher DI-GM scores were significantly associated with lower VAT mass in United States adults. Prospective studies are needed to confirm these findings and establish causal relationships.
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