ArticleActa neuropathologica communications2026
Rapid intraoperative boundary diagnosis of somatotroph pituitary neuroendocrine tumors using real-time PCR.
Article in Acta neuropathologica communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Pituitary neuroendocrine tumors (PitNETs) are generally benign; however, functional subtypes cause hormone hypersecretion, leading to systemic complications. In somatotroph PitNETs, growth hormone (GH) excess increases mortality and necessitates complete tumor resection to achieve endocrinological remission. Although extracapsular resection along the pseudocapsule is preferred, the plane may be poorly defined with tumor cells infiltrating adjacent normal tissue, necessitating further resection of the outer layer. Conversely, excessive resection increases the risk of postoperative hypopituitarism; therefore, precise intraoperative delineation of tumor boundaries is essential. Approximately half of the somatotroph PitNETs harbor GNAS mutations. We used a microfluidic real-time PCR platform (GeneSoC
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