ReviewBMC genomics2026
Illuminating the mechanism: gene expression responses to antimicrobial photodynamic therapy.
Review in BMC genomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Photodynamic treatments are promising antimicrobial approaches that rely on the generation of reactive oxygen species (ROS), which lead to damage to bacterial cell structures. As the number of studies investigating gene expression changes in microorganisms following antimicrobial photodynamic inactivation (aPDI) and antimicrobial blue light (aBL) exposure is steadily increasing, there is a clear need for a comprehensive review that synthesizes these findings. This article aims to address this gap by presenting the current state of knowledge on transcriptomic alterations induced by photodynamic therapies, with a particular focus on studies utilizing qPCR and RNA-seq methodologies. Investigated genes were divided into key functional categories associated with virulence factors, DNA repair, detoxification and oxidative stress response, defense mechanisms and cellular metabolism. A general trend toward reduced expression of virulence-related genes has been observed, indicating the potential of these methods not only in eradicating bacteria but also in reducing their pathogenicity. Increased expression of certain genes linked with oxidative stress response and heat shock proteins may reflect adaptive or compensatory survival mechanisms. Differences in experimental results are often due to different protocols regarding the type of photosensitizer, wavelength of light or phase of bacterial growth.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.