ArticleGlia2026
Neuronal Activity Promotes Node-Like Cluster Assembly Prior to Myelination and Remyelination in the Central Nervous System.
Article in Glia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Glutamate signaling and transport around nodes of Ranvier and internodal myelin regions.Histology and histopathology · 2026Review
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
In recent years, myelination has been recognized as a key process in neural plasticity and network refinement, in addition to its role in axonal conduction and neuronal metabolic support. The fast saltatory conduction along myelinated fibers relies on the nodes of Ranvier. Node-like clusters can form prior to myelin deposition in development and repair and can regulate axonal conduction, myelin deposition initiation, as well as contribute to the formation of mature nodes of Ranvier. In this study, we show that node-like cluster assembly is modulated by neuronal activity and could thus be an intermediate step in activity-induced (re)myelination. We further identify the regulation of Nav1.1 expression, which we show to be required for node-like cluster formation, as part of the molecular mechanism implicated in the activity-dependent regulation of node-like cluster assembly. This process may serve in shaping neuronal networks and myelin patterns during development, plasticity and repair.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.