Evidence map›Paper›PMID 41731302›Full record

ArticleMagnetic resonance in medicine2026

Absolute Quantification of Brain Deuterium Metabolic Imaging in Healthy Volunteers and Glioblastoma Patients at 7T.

Jabrane Karkouri, Masha Novoselova, Sarah Miller, Minghao Zhang, Alexandra Constantinou, Carina Graf, Özlem Ipek, Daniel Atkinson, Brandon Tramm, Scott Schillak and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Magnetic resonance in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jabrane KarkouriWolfson Brain Imaging Centre, University of Cambridge, Cambridge, UK.ORCID 0000-0002-3857-0119
Masha NovoselovaWolfson Brain Imaging Centre, University of Cambridge, Cambridge, UK.ORCID 0009-0005-5043-6261
Sarah MillerWolfson Brain Imaging Centre, University of Cambridge, Cambridge, UK.
Minghao ZhangWolfson Brain Imaging Centre, University of Cambridge, Cambridge, UK.ORCID 0000-0002-5401-6070
Alexandra ConstantinouWolfson Brain Imaging Centre, University of Cambridge, Cambridge, UK.
Carina GrafWolfson Brain Imaging Centre, University of Cambridge, Cambridge, UK.
Özlem IpekSchool of Biomedical Engineering and Imaging Science, King's College London, London, UK.ORCID 0000-0001-5233-1600
Daniel AtkinsonWolfson Brain Imaging Centre, University of Cambridge, Cambridge, UK.
Brandon TrammVirtumed, LLC, Minneapolis, Minnesota, USA.
Scott SchillakVirtumed, LLC, Minneapolis, Minnesota, USA.
Richard MairCancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, UK.
Kevin BrindleCancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, UK.ORCID 0000-0003-3883-6287
Christopher T RodgersWolfson Brain Imaging Centre, University of Cambridge, Cambridge, UK.ORCID 0000-0003-1275-1197

Funding

Armstrong Fund and the European Union's H2020 research and innovation program 801075Cambridge TrustCommonwealth Scholarship CommissionCRUK Rosetta Grand Challenge A25045EU Horizon Europe project 101058229Medical Research Council MR N013433-1Medical Research Council UKRI2679Medical Research Council UKRI790NIHR Applied Research Collaboration East of EnglandNIHR Cambridge Biomedical Research Centre NIHR203312
6 · The paper itself

Abstract

purposeWe present a method for absolute quantification of deuterated metabolites in vivo at 7T. We describe acquisition protocols and an analysis pipeline compatible with 7T Terra MRIs. We apply them using a

methodsB

resultsMeasured B

conclusionWe demonstrate robust absolute quantification for human 7T DMI. Glioblastoma tumors showed elevated Lac and reduced Glx labeling relative to normal brain, with inter-patient heterogeneity consistent with an existence of different metabolic subtypes.

Indexed as

BrainBrain NeoplasmsDeuteriumGlioblastomaMagnetic Resonance ImagingAdultAgedFemaleGlucoseHealthy VolunteersHumansImage Processing, Computer-AssistedMaleMiddle AgedPhantoms, ImagingReproducibility of ResultsDeuteriumGlucosearray head coilsbrain metabolismbrain tumordeuterium metabolic imagingglioblastoma

Identifiers

PMID41731302
PMCPMC13049263

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.