Evidence map›Paper›PMID 41731290›Full record

ArticleGeroScience2026

Circulating endotrophin reflects inflammaging and mortality risk in older adults.

Clara F G Laursen, Federica Genovese, Morten Baltzer Houlind, Aino Leegaard Andersen, Morten Karsdal, Line J H Rasmussen, Juliette Tavenier

Abstract read
PubMed Publisher
In one paragraph

Article in GeroScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Clara F G LaursenDepartment of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark. cla@nordicbio.com.ORCID http://orcid.org/0009-0008-2227-4535
Federica GenoveseNordic Bioscience AS, Herlev Hovedgade 205, 2730, Herlev, Denmark.
Morten Baltzer HoulindDepartment of Clinical Research, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark.
Aino Leegaard AndersenDepartment of Clinical Research, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark.
Morten KarsdalNordic Bioscience AS, Herlev Hovedgade 205, 2730, Herlev, Denmark.
Line J H RasmussenDepartment of Clinical Research, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark.
Juliette TavenierDepartment of Clinical Research, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark.

Funding

Region Hovedstaden 2024-0014Region Hovedstaden 2024-0066
6 · The paper itself

Abstract

Although interest in biomarkers of biological aging is growing, consensus on reliable, non-invasive indicators remains limited. Endotrophin, a bioactive fragment released during collagen type VI formation, reflects fibroblast activation and extracellular matrix remodeling and has been linked to chronic diseases, metabolic dysfunction, and inflammation. Whether circulating endotrophin also captures aging-related phenotypes and mortality risk in older adults remains unclear. We quantified serum endotrophin by the PRO-C6 assay in 1) acutely hospitalized Older patients (n = 121) at admission (T

Indexed as

Biological agingBiomarkersExtracellular matrixFibrosisInflammationMortality

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.