Evidence map›Paper›PMID 41731282›Full record

ReviewDrugs2026

Developing CRISPR-Based Therapies for Epidermolysis Bullosa: A Comprehensive Review of Current Strategies.

Alex du Rand, Ben Buttle, Hilary Sheppard

Abstract readReview
In one paragraph

Review in Drugs, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Alex du RandSchool of Biological Sciences, The University of Auckland, Auckland, New Zealand.ORCID http://orcid.org/0000-0002-9481-4149
Ben ButtleSchool of Biological Sciences, The University of Auckland, Auckland, New Zealand.ORCID http://orcid.org/0009-0000-0320-8569
Hilary SheppardSchool of Biological Sciences, The University of Auckland, Auckland, New Zealand. h.sheppard@auckland.ac.nz.ORCID http://orcid.org/0000-0003-1147-4618

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Currently, there is no permanent treatment for the group of severe monogenic fragile skin conditions epidermolysis bullosa (EB). The recent US Food and Drug Administration (FDA)-approved in vivo gene replacement therapy beremagene geperpavec (Vyjuvek

Indexed as

Clustered Regularly Interspaced Short Palindromic RepeatsCRISPR-Cas SystemsEpidermolysis BullosaGene EditingGenetic TherapyAnimalsGene Therapy AgentsHumans

Identifiers

PMID41731282
PMCPMC13005845

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.