Evidence map›Paper›PMID 41731168›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2026

Design, synthesis, and mechanistic evaluation of propargylated salicylaldehyde derivatives as dual apoptosis-autophagy modulator for pancreatic cancer.

Filiz Taspinar, Karina Amudi, Nurettin Menges

Abstract read
In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Filiz TaspinarDepartment of Physiology, Faculty of Medicine, Aksaray University, Aksaray, 68300, Türkiye. filiztaspinar@aksaray.edu.tr.
Karina AmudiScience and Technology Research and Application Center (BITAM), Necmettin Erbakan University, Konya, 42090, Türkiye.
Nurettin MengesScience and Technology Research and Application Center (BITAM), Necmettin Erbakan University, Konya, 42090, Türkiye. nurettin.menges@erbakan.edu.tr.

Funding

Necmettin Erbakan Üniversitesi 2217MER03007
6 · The paper itself

Abstract

In this study, eight novel propargylated salicylaldehyde derivatives and one propargylated indole derivative were successfully synthesized and evaluated for their cytotoxic activities against the human pancreatic cancer cell line PANC-1. Among the nine tested molecules, molecules 4 and 6 exhibited the most pronounced cytotoxic effects, with IC

Indexed as

AldehydesAntineoplastic AgentsApoptosisAutophagyDrug DesignPancreatic NeoplasmsCell Line, TumorHumansMolecular Docking SimulationStructure-Activity RelationshipAldehydesAntineoplastic AgentssalicylaldehydeApoptosisAutophagyGene expressionSpectral analysisSubstitution

Identifiers

PMID41731168
PMCPMC13269460

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.