Evidence map›Paper›PMID 41731154›Full record

ReviewArchives of virology2026

The multifaceted roles of fibronectin in viral pathogenesis.

Munirah Faleh Alenezi, Jasmine E Khairat, Muhamad Afiq Aziz, Pouya Hassandarvish

Abstract readReview
PubMed Publisher
In one paragraph

Review in Archives of virology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Munirah Faleh AleneziInstitute of Biological Sciences (ISB), Faculty of Science, Universiti Malaya, Kuala Lumpur, Malaysia.
Jasmine E KhairatInstitute of Biological Sciences (ISB), Faculty of Science, Universiti Malaya, Kuala Lumpur, Malaysia. jasmine@um.edu.my.ORCID http://orcid.org/0000-0001-9419-5731
Muhamad Afiq AzizInstitute of Biological Sciences (ISB), Faculty of Science, Universiti Malaya, Kuala Lumpur, Malaysia.
Pouya HassandarvishTropical Infectious Diseases Research and Education Centre, Universiti Malaya, Kuala Lumpur, 50603, Malaysia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fibronectin is a high molecular weight glycoprotein critical to numerous physiological and pathological processes, including extracellular matrix organization, wound healing, immune responses, and interactions with pathogens. Evidence from various viral systems, including dengue, influenza, hepatitis B, and HIV-1, indicates that targeting fibronectin or disrupting its interactions can notably affect outcomes of viral infections in vitro. Alterations in the expression of fibronectin are associated with immune evasion mechanisms, including the inhibition of interferon signaling, thereby enabling viruses to survive and replicate with greater efficacy. In this review, we discuss how viruses can interact with fibronectin through arginyl-glycyl-aspartic acid motif (RGD) mimicry or other mechanisms. Finally, we explore the role of fibronectin in modulating host immune responses and its potential as a therapeutic target.

Indexed as

FibronectinsVirus DiseasesVirusesAnimalsHost-Pathogen InteractionsHumansImmune EvasionOligopeptidesVirus Internalizationarginyl-glycyl-aspartic acidFibronectinsOligopeptidesFibronectinImmune responseRGD motifViral entry

Identifiers

PMID41731154

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.