ArticleVirchows Archiv : an international journal of pathology2026
A case of ovarian Sertoli-Leydig cell tumor with high grade transformation harbouring DICER1 and TP53 mutations.
Article in Virchows Archiv : an international journal of pathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Sertoli-Leydig cell tumor (SLCT) is a rare ovarian sex cord-stromal tumor that may occur sporadically or in the context of DICER1 syndrome. We present a case of ovarian SLCT with high-grade transformation in a 73-year-old patient. The tumor showed typical morphology and immunophenotype of moderately differentiated SLCT with distinct areas of high-grade transformation. NGS DNA sequencing revealed two somatic DICER1 mutations. In addition, a pathogenic TP53 mutation was detected exclusively in the high-grade area. This case represents only the second documented ovarian SLCT with confirmed high-grade transformation supported by a concurrent TP53 alteration.
Indexed as
Identifiers
41731128What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.