Evidence map›Paper›PMID 41731054›Full record

ArticleCommunications biology2026

Obesogenic effects of warm temperature involve feeding adaptation by preoptic area leptin receptor neurons.

Laura Kaiser, Nathan Lee, Katelynn Zaunbrecher, Clint Kinney, Jaclyn Williams, Michael Smith, Robert C Noland, Sangho Yu, Christopher D Morrison, Hans-Rudolf Berthoud and 1 more

Abstract read
In one paragraph

Article in Communications biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Laura KaiserNeurobiology of Nutrition and Metabolism Department, Pennington Biomedical Research Center (PBRC), LSU System, Baton Rouge, LA, USA.ORCID http://orcid.org/0000-0002-4971-0586
Nathan LeeNeurobiology of Nutrition and Metabolism Department, Pennington Biomedical Research Center (PBRC), LSU System, Baton Rouge, LA, USA.
Katelynn ZaunbrecherNeurobiology of Nutrition and Metabolism Department, Pennington Biomedical Research Center (PBRC), LSU System, Baton Rouge, LA, USA.ORCID http://orcid.org/0009-0001-7063-5197
Clint KinneyNeurobiology of Nutrition and Metabolism Department, Pennington Biomedical Research Center (PBRC), LSU System, Baton Rouge, LA, USA.
Jaclyn WilliamsNeurobiology of Nutrition and Metabolism Department, Pennington Biomedical Research Center (PBRC), LSU System, Baton Rouge, LA, USA.
Michael SmithNeurobiology of Nutrition and Metabolism Department, Pennington Biomedical Research Center (PBRC), LSU System, Baton Rouge, LA, USA.
Robert C NolandNeurobiology of Nutrition and Metabolism Department, Pennington Biomedical Research Center (PBRC), LSU System, Baton Rouge, LA, USA.ORCID http://orcid.org/0000-0001-5543-3450
Sangho YuNeurobiology of Nutrition and Metabolism Department, Pennington Biomedical Research Center (PBRC), LSU System, Baton Rouge, LA, USA.ORCID http://orcid.org/0000-0002-2973-7562
Christopher D MorrisonNeurobiology of Nutrition and Metabolism Department, Pennington Biomedical Research Center (PBRC), LSU System, Baton Rouge, LA, USA.ORCID http://orcid.org/0000-0002-5492-102X
Hans-Rudolf BerthoudNeurobiology of Nutrition and Metabolism Department, Pennington Biomedical Research Center (PBRC), LSU System, Baton Rouge, LA, USA.ORCID http://orcid.org/0000-0003-0787-1709
Heike MünzbergNeurobiology of Nutrition and Metabolism Department, Pennington Biomedical Research Center (PBRC), LSU System, Baton Rouge, LA, USA. Heike.Munzberg@pbrc.edu.ORCID http://orcid.org/0000-0002-1152-4884

Funding

Leptin and Central Control of ThermoregulationR01DK092587 · NIDDK · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI MUENZBERG-GRUENING, HEIKE · 2012 to 2024
$3.5M
Metabolic Changes: Connecting temperature sensing neurons to sympathetic adipose tissue stimulationR01AT011683 · NCCIH · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI MUENZBERG-GRUENING, HEIKE · 2021 to 2025
$2.5M
NCCIH NIH HHS R01 AT011683NIDDK NIH HHS R01 DK092587U.S. Department of Health & Human Services | NIH | National Center for Complementary and Integrative Health (NCCIH) R01AT011683U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) 2R01DK092587U.S. Department of Health & Human Services | NIH | NIH Office of the Director (OD) 1-OT2OD023864-01
6 · The paper itself

Abstract

The preoptic area (POA) is a well-established regulator of body temperature, but its role in feeding behavior remains underexplored. Our study identifies leptin receptor (Lepr)-expressing neurons in the POA (POA

Indexed as

Adaptation, PhysiologicalFeeding BehaviorHot TemperatureNeuronsObesityPreoptic AreaReceptors, LeptinAnimalsBody Temperature RegulationEatingFemaleMaleMiceReceptor, Melanocortin, Type 4Receptor, Melanocortin, Type 4Receptors, Leptin

Identifiers

PMID41731054
PMCPMC13039313

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.