Evidence map›Paper›PMID 41730984›Full record

ArticleScientific reports2026

Single cell multiomic landscape reveals gene programs driving lipid droplet heterogeneity in hepatic steatosis.

Tejasav S Sehrawat, Shawna A Cooper, Amaia Navarro-Corcuera, Ryan J Schulze, Mengfei Liu, Usman Yaqoob, Yubin Yeon, Sangwoong Yoon, Yung-Kyun Noh, Chady Meroueh and 15 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Ethanol reshapes FFC-driven steatohepatitis through time-dependent fibrosis and lipid-droplet remodeling.American journal of physiology. Gastrointestinal and liver physiology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Tejasav S Sehrawat *Division of Gastroenterology and Hepatology, Department of Internal Medicine, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA.
Shawna A Cooper *Division of Gastroenterology and Hepatology, Department of Internal Medicine, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA.
Amaia Navarro-CorcueraDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA.
Ryan J SchulzeDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA.
Mengfei LiuDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA.
Usman YaqoobDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA.
Yubin YeonDepartment of Artificial Intelligence, Hanyang University, Seoul, Republic of Korea.
Sangwoong YoonUniversity College London, London, UK.
Yung-Kyun NohSchool of Computational Sciences, Korea Institute for Advanced Study, Seoul, Republic of Korea.
Chady MerouehDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
Joseph C AhnDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA.
Josepmaria ArgemiDivision of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh, Pittsburgh, PA, USA.
Ramon A BatallerDivision of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh, Pittsburgh, PA, USA.
Mark A McNivenDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA.
Mrunal K DehankarDivision of Computational Biology, Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.
Ying LiDivision of Computational Biology, Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.
Jeong-Heon LeeCenter for Individualized Medicine, Mayo Clinic, Rochester, MN, USA.
Carol A CaseyDepartment of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, USA.
William A FaubionDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA.
Tamas OrdogDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA.
Patrick S KamathDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA.
Douglas A SimonettoDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA.
Harmeet MalhiDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA.
Sheng CaoDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA. cao.sheng@mayo.edu.
Vijay H ShahDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA. shah.vijay@mayo.edu.

Funding

IL17 dependent angiocrine signaling drives inflammation in alcohol associated hepatitisK08AA030587 · NIAAA · YALE UNIVERSITY · PI Mengfei Liu · 2022 to 2026
$1.0M
Korean Grant 2020-0-01373NIAAA NIH HHS K08 AA030587NIH HHS AA21788
6 · The paper itself

Abstract

Alcohol-associated liver disease (ALD) in its earliest form is evidenced as hepatic steatosis which may progress to liver cirrhosis. The mechanisms behind this are poorly understood and therapeutics limited. Liver is a specialized organ exhibiting heterogeneity along the porto-central axis. Periportal preponderance of lipid droplet accumulation was noted in human ALD livers compared to other causes of hepatic steatosis. Using single cell multiomics, we studied transcriptional mechanisms across the hepatic lobule that could account for zonation of lipid droplets in a murine ALD model. Alcohol led to periportal zonation of lipogenesis-associated genes in mice, including Hsd17b13 and Fasn. Chromatin landscape studies demonstrated zonation of master transcription factors that led to these changes in the transcriptome. We utilized these data to provide novel insight into zone-specific HNF4α and PPARα regulation of HSD17B13. We conclude novel mechanisms underlying ALD leading to spatially distinct establishment of hepatic steatosis and provide insight into disease pathogenesis.

Indexed as

Fatty LiverFatty Liver, AlcoholicLipid Droplets17-Hydroxysteroid DehydrogenasesAnimalsDisease Models, AnimalFatty Acid Synthase, Type IGene Expression RegulationHepatocyte Nuclear Factor 4HumansLipogenesisLiverMaleMiceMultiomicsPPAR alpha17-Hydroxysteroid DehydrogenasesFasn protein, mouseFatty Acid Synthase, Type IHepatocyte Nuclear Factor 4Hnf4a protein, mousePPAR alphaPpara protein, mouse

Identifiers

PMID41730984
PMCPMC13031360

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.