Evidence map›Paper›PMID 41730978›Full record

ReviewCommunications chemistry2026

Advances in solid handling for continuous flow synthesis of specialty chemicals and pharmaceuticals.

Zen Johnston, Thabo Peme, Tommy Mabasa, Christophe Len, Darren Riley, Jenny-Lee Panayides, Cloudius Ray Sagandira

Abstract readReview
In one paragraph

Review in Communications chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zen JohnstonDepartment of Chemistry, University of Pretoria, Pretoria, South Africa.ORCID http://orcid.org/0000-0003-3035-390X
Thabo PemeDepartment of Chemistry, University of Pretoria, Pretoria, South Africa.
Tommy MabasaPharmaceutical Technologies, Council for Scientific and Industrial Research, Pretoria, South Africa.ORCID http://orcid.org/0000-0003-4001-3896
Christophe LenChimie ParisTech, CNRS, PSL Research University, Institute of Chemistry for Life and Health Sciences, Paris, France.
Darren RileyDepartment of Chemistry, University of Pretoria, Pretoria, South Africa.
Jenny-Lee PanayidesPharmaceutical Technologies, Council for Scientific and Industrial Research, Pretoria, South Africa.
Cloudius Ray SagandiraPharmaceutical Technologies, Council for Scientific and Industrial Research, Pretoria, South Africa. csagandira@csir.co.za.ORCID http://orcid.org/0000-0002-6485-3606

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Continuous flow chemistry has transformed the synthesis of pharmaceuticals and specialty chemicals by advancing sustainability, efficiency, and process control. Despite these advantages, the management of solids remains a major challenge, often leading to clogging, inefficient mixing, and limitations in scalability. This review discusses recent strategies developed to overcome these obstacles, including the use of continuous stirred-tank reactors, packed-bed reactors with immobilized reagents, reaction design modifications, Pickering emulsions, colloidal nanoparticle suspensions, and specialised equipment such as agitated tubular reactors, spinning disk reactors, and sonicated systems. By critically assessing these developments, we chart the trajectory toward more resilient and robust flow-based manufacturing, consolidating continuous flow chemistry as a cornerstone of modern chemical manufacturing.

Identifiers

PMID41730978
PMCPMC12929740

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.