ArticleScientific reports2026
FTY-720 pre-treatment attenuates acute lung injury following bilateral renal ischemia/reperfusion but not bilateral nephrectomy.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Acute kidney injury (AKI) frequently coexists with acute lung injury (ALI) in critically ill patients, resulting in high mortality rates in intensive care units. This study aimed to investigate the role of lymphocytes in ALI following bilateral renal ischemia and bilateral nephrectomy, using FTY-720 (Fingolimod), which inhibits lymphocyte release into the circulation. The study was conducted on 75 male Sprague-Dawley rats, which were divided into five groups: three untreated groups subjected to bilateral renal ischemia/reperfusion (BIR), bilateral nephrectomy (BNX), or a sham operation, and two groups pre-treated with FTY-720 followed by either BIR (BIR + FTY) or BNX (BNX + FTY). One hour of bilateral renal ischemia followed by 24 h of reperfusion caused severe kidney tissue damage and impaired renal hemodynamic, excretory, and urine-concentrating functions. These alterations were accompanied by significant increases in plasma creatinine, urea, K
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