ArticleNature communications2026
A testis-specific E3 ubiquitin ligase complex governs spermiogenesis and male fertility.
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Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1citing papers in PubMed
–field-weighted citation impact
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1 citing paper in PubMed.
- WSB1 is dispensable for mouse spermatogenesis and male fertility.American journal of translational research · 2026Article
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Authors and funding
30 authors.
Tiantian Wu *State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproduction and Genetics, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, China.
Chaofeng Tu *Institute of Reproductive and Stem Cell Engineering, NHC Key Laboratory of Human Stem Cell and Reproductive Engineering, Xiangya School of Basic Medical Science, Central South University, Changsha, China.
Yuxuan Feng *Department of Histology and Embryology, School of Basic Medical Sciences, State Key Laboratory of Reproductive Medicine and Offspring Health, Nanjing Medical University, Nanjing, China.
Wenying Qu *State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproduction and Genetics, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, China.
Jinyi Chen *Department of Histology and Embryology, School of Basic Medical Sciences, State Key Laboratory of Reproductive Medicine and Offspring Health, Nanjing Medical University, Nanjing, China.ORCID http://orcid.org/0009-0009-9895-2280
Huan Wu *Department of Obstetrics and Gynecology, Reproductive Medicine Center, The First Affiliated Hospital of Anhui Medical University, Hefei, China.ORCID http://orcid.org/0000-0002-0009-3839
Wenxin GaoDepartment of Histology and Embryology, School of Basic Medical Sciences, State Key Laboratory of Reproductive Medicine and Offspring Health, Nanjing Medical University, Nanjing, China.
Bingya XuState Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproduction and Genetics, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, China.
Xiangling YuState Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproduction and Genetics, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, China.
Mingyuan BaoDepartment of Histology and Embryology, School of Basic Medical Sciences, State Key Laboratory of Reproductive Medicine and Offspring Health, Nanjing Medical University, Nanjing, China.
Jinfu XuDepartment of Histology and Embryology, School of Basic Medical Sciences, State Key Laboratory of Reproductive Medicine and Offspring Health, Nanjing Medical University, Nanjing, China.
Nianchao ZhouState Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproduction and Genetics, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, China.
Haoyue HuState Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproduction and Genetics, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, China.
Bing JiangState Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproduction and Genetics, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, China.
Qingsong XieDepartment of Obstetrics and Gynecology, Reproductive Medicine Center, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Lanlan MengInstitute of Reproductive and Stem Cell Engineering, NHC Key Laboratory of Human Stem Cell and Reproductive Engineering, Xiangya School of Basic Medical Science, Central South University, Changsha, China.
Chen TanInstitute of Reproductive and Stem Cell Engineering, NHC Key Laboratory of Human Stem Cell and Reproductive Engineering, Xiangya School of Basic Medical Science, Central South University, Changsha, China.
Ge LinInstitute of Reproductive and Stem Cell Engineering, NHC Key Laboratory of Human Stem Cell and Reproductive Engineering, Xiangya School of Basic Medical Science, Central South University, Changsha, China.ORCID http://orcid.org/0000-0002-3877-2546
Cong ShenState Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproduction and Genetics, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, China.ORCID http://orcid.org/0000-0002-9982-176X
Xia ChenDepartment of Obstetrics and Gynecology, Center of Reproductive Medicine, Affiliated Hospital of Nantong University, Nantong, China.
Yueshuai GuoDepartment of Histology and Embryology, School of Basic Medical Sciences, State Key Laboratory of Reproductive Medicine and Offspring Health, Nanjing Medical University, Nanjing, China.ORCID http://orcid.org/0000-0002-2719-1244
Tao ZhouScientific Research Center, Gannan Medical University, Ganzhou, China.ORCID http://orcid.org/0000-0003-2219-6385
Yuting LiangCenter for Clinical Laboratory, The First Affiliated Hospital of Soochow University, Suzhou, China.
Rong HuaDepartment of Obstetrics and Gynecology, Reproductive Medicine Center, The First Affiliated Hospital of Anhui Medical University, Hefei, China.ORCID http://orcid.org/0000-0001-9607-6605
Yunxia CaoDepartment of Obstetrics and Gynecology, Reproductive Medicine Center, The First Affiliated Hospital of Anhui Medical University, Hefei, China.ORCID http://orcid.org/0000-0002-8715-0874
Mingxi LiuDepartment of Histology and Embryology, School of Basic Medical Sciences, State Key Laboratory of Reproductive Medicine and Offspring Health, Nanjing Medical University, Nanjing, China. mingxi.liu@njmu.edu.cn.ORCID http://orcid.org/0000-0001-6499-7899
Jun YuInstitute of Reproductive Medicine, Medical School of Nantong University, Nantong University, Nantong, China. yujun9117@126.com.ORCID http://orcid.org/0000-0003-3109-4102
Xiaoyan HuangDepartment of Histology and Embryology, School of Basic Medical Sciences, State Key Laboratory of Reproductive Medicine and Offspring Health, Nanjing Medical University, Nanjing, China. bbhxy@njmu.edu.cn.ORCID http://orcid.org/0000-0002-9766-2371
Yue-Qiu TanInstitute of Reproductive and Stem Cell Engineering, NHC Key Laboratory of Human Stem Cell and Reproductive Engineering, Xiangya School of Basic Medical Science, Central South University, Changsha, China. tanyueqiu@csu.edu.cn.ORCID http://orcid.org/0000-0002-8359-4654
Bo ZhengState Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproduction and Genetics, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, China. bozheng@njmu.edu.cn.ORCID http://orcid.org/0000-0002-1496-0753
Funding
National Natural Science Foundation of China (National Science Foundation of China) 32370903National Natural Science Foundation of China (National Science Foundation of China) 32470899National Natural Science Foundation of China (National Science Foundation of China) 82271633National Natural Science Foundation of China (National Science Foundation of China) 82471641
Abstract
The ubiquitin-proteasome system (UPS) represents an evolutionarily conserved machinery governing proteostasis through spatiotemporal regulation of protein degradation. While spermatogenesis involves multilayered regulatory mechanisms spanning translation to dynamic post-translational modifications (PTMs), the identity of UPS-associated E3 ligases orchestrating germ cell-specific protein turnover remains elusive. Here, we identify a testis-specific E3 ubiquitin ligase complex comprising elongin B/C, Cullin-2 (CUL2), RING-box protein-1 (RBX1), and SOCS box protein ASB9, designated ECS
Indexed as
FertilityInfertility, MaleSpermatogenesisTestisUbiquitin-Protein LigasesAnimalsElonginHumansMaleMiceMice, KnockoutProteasome Endopeptidase ComplexTubulinUbiquitinationElonginProteasome Endopeptidase ComplexTubulinUbiquitin-Protein Ligases
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LicenceCC BY-NC-ND
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.