Evidence map›Paper›PMID 41730890›Full record

ArticleNature communications2026

Direct synthesis of bicyclo[1.1.1]pentane (BCP) boronates from carboxylic acids.

Yongchen Wang, Jess C Tang, Gang Wu, Julian G West

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yongchen WangDepartment of Chemistry, Biosciences Research Collaborative, Rice University, Houston, TX, USA.
Jess C TangDepartment of Chemistry, Biosciences Research Collaborative, Rice University, Houston, TX, USA.
Gang WuDepartment of Internal Medicine, University of Texas- McGovern Medical School, Houston, TX, USA.ORCID http://orcid.org/0000-0001-6803-0853
Julian G WestDepartment of Chemistry, Biosciences Research Collaborative, Rice University, Houston, TX, USA. jgwest@rice.edu.ORCID http://orcid.org/0000-0002-3715-7883

Funding

New Frontiers in Chemical Reactivity Via Catalytic Hydrogen Atom TransferR35GM142738 · NIGMS · RICE UNIVERSITY · PI Julian G West · 2021 to 2026
$2.3M
Cancer Prevention and Research Institute of Texas (Cancer Prevention Research Institute of Texas) RR190025Eli Lilly and Company (Lilly) A-36829NIGMS NIH HHS R35 GM142738Research Corporation for Scientific Advancement (RCSA) CS-CSA-2023-007U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) R35GM142738Welch Foundation C-2085
6 · The paper itself

Abstract

Bicyclo[1.1.1]pentane (BCP) boronic esters are crucial intermediates for accessing BCP-containing drugs with improved pharmacokinetic profiles, yet their synthesis typically relies on pre-formed redox-active esters derived from carboxylic acids. Here we report a general, single-step method for the direct conversion of carboxylic acids into BCP boronic esters. Upon irradiation of carboxylic acids with [1.1.1]propellane and bis(pinacolato)diboron (B

Identifiers

PMID41730890
PMCPMC13039371

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.