Evidence map›Paper›PMID 41730883›Full record

ArticleNature communications2026

Structural and dynamic insights into agonist recognition and function of the thromboxane A

Pawel Krawinski, Donna Matzov, Aoife Ryder, Kanhaya Lal, Dmitry S Karlov, Georges Chalhoub, Eamon P Mulvaney, B Therese Kinsella, Peter J McCormick, Martin Caffrey and 2 more

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. New insights into flavonoid binding to the thromboxane ABlood vessels, thrombosis & hemostasis · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Pawel Krawinski *School of Medicine and School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland.ORCID http://orcid.org/0000-0002-2611-6410
Donna Matzov *Department of Chemical and Structural Biology, Weizmann Institute of Science, Rehovot, Israel.
Aoife RyderSchool of Medicine and School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland.
Kanhaya LalSchool of Pharmacy, Queen's University Belfast, Belfast, UK.
Dmitry S KarlovSchool of Pharmacy, Queen's University Belfast, Belfast, UK.
Georges ChalhoubDepartment of Pharmacology and Therapeutics, University of Liverpool, Institute of Systems, Molecular and Integrative Biology, Sherrington Building, Liverpool, UK.
Eamon P MulvaneyATXA Therapeutics Limited, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Ireland.ORCID http://orcid.org/0000-0003-3661-2116
B Therese KinsellaATXA Therapeutics Limited, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Ireland.ORCID http://orcid.org/0000-0003-3072-941X
Peter J McCormickDepartment of Pharmacology and Therapeutics, University of Liverpool, Institute of Systems, Molecular and Integrative Biology, Sherrington Building, Liverpool, UK.ORCID http://orcid.org/0000-0002-2225-5181
Martin CaffreySchool of Medicine and School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland. martin.caffrey@tcd.ie.ORCID http://orcid.org/0000-0002-2931-4551
Irina G TikhonovaSchool of Pharmacy, Queen's University Belfast, Belfast, UK. i.tikhonova@qub.ac.uk.ORCID http://orcid.org/0000-0002-6228-9431
Moran Shalev-BenamiDepartment of Chemical and Structural Biology, Weizmann Institute of Science, Rehovot, Israel. moransb@weizmann.ac.il.ORCID http://orcid.org/0000-0001-6902-1924

Funding

EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 European Research Council (H2020 Excellent Science - European Research Council) 949364Irish Research Council for Science, Engineering and Technology (IRCSET) GOIPG/2019/3074RCUK | Biotechnology and Biological Sciences Research Council (BBSRC) BB/R007101/1RCUK | Engineering and Physical Sciences Research Council (EPSRC) EP/T022175/1RCUK | Engineering and Physical Sciences Research Council (EPSRC) EP/W03204X/1Science Foundation Ireland (SFI) 16/IA/4435Science Foundation Ireland (SFI) 22/FFP-A/10278
6 · The paper itself

Abstract

The thromboxane A

Indexed as

Receptors, Thromboxane A2, Prostaglandin H215-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic AcidAnimalsBinding SitesBridged Bicyclo Compounds, HeterocyclicGTP-Binding Protein alpha Subunits, Gq-G11HumansLigandsMolecular Docking SimulationMolecular Dynamics SimulationProtein BindingThromboxane A215-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic AcidBridged Bicyclo Compounds, HeterocyclicGTP-Binding Protein alpha Subunits, Gq-G11LigandsReceptors, Thromboxane A2, Prostaglandin H2Thromboxane A2

Identifiers

PMID41730883
PMCPMC13039517

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.