ArticleChemical research in toxicology2026
Naphthalene-DNA Adduct Formation in a Lung Airway Explant Model: The Role of Bioactivation and Naphthalene Metabolites.
Morgan C Domanico, Sarah A Carratt, Nicole Collette, Esther A Ubick, Patricia C Edwards, Weizhu Yang, Bruce A Buchholz, Xinxin Ding, Laura S Van Winkle
Abstract read
In one paragraphArticle in Chemical research in toxicology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
9 authors.
Morgan C DomanicoCenter for Health and the Environment, University of California Davis, Davis, California 95616, United States.ORCID 0000-0003-4879-5597 Sarah A CarrattCenter for Health and the Environment, University of California Davis, Davis, California 95616, United States.
Nicole ColletteBiosciences & Biotechnology Division, Lawrence Livermore National Laboratory, Livermore, California 94550, United States.ORCID 0000-0002-9068-8712 Esther A UbickBiosciences & Biotechnology Division, Lawrence Livermore National Laboratory, Livermore, California 94550, United States.
Patricia C EdwardsCenter for Health and the Environment, University of California Davis, Davis, California 95616, United States.
Weizhu YangDepartment of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, Arizona 85721, United States.
Bruce A BuchholzCenter for Accelerator Mass Spectrometry, Lawrence Livermore National Laboratory, Livermore, California 94550, United States.
Xinxin DingDepartment of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, Arizona 85721, United States.
Laura S Van WinkleCenter for Health and the Environment, University of California Davis, Davis, California 95616, United States.
Funding
UC Davis Environmental Health Sciences Core CenterP30ES023513 · NIEHS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Irva Hertz-Picciotto · 2015 to 2026
$26.0MResource for the Development of Biomedical Accelerator Mass Spectrometry (AMS)P41GM103483 · NIGMS · UNIVERSITY OF CALIF-LAWRNC LVRMR NAT LAB · PI TURTELTAUB, KENNETH W. · 2012 to 2019
$12.0MNational User Resource for Biological Accelerator Mass SpectrometryR24GM137748 · NIGMS · LAWRENCE LIVERMORE NATIONAL SECURITY, LLC · PI BENCH, GRAHAM · 2020 to 2024
$6.5MMetabolic Mechanisms of Naphthalene Toxicity in LungR01ES020867 · NIEHS · WADSWORTH CENTER · PI Xinxin Ding, Laura S Van Winkle · 2013 to 2026
$6.4MNIEHS NIH HHS P30 ES023513NIEHS NIH HHS R01 ES020867NIGMS NIH HHS P41 GM103483NIGMS NIH HHS R24 GM137748
6 · The paper itselfAbstract
Humans are widely exposed to naphthalene. Once inhaled or ingested, naphthalene is metabolized by cytochrome P450 and other enzymes to form toxic metabolites known to harm lung epithelial cells. Naphthalene metabolites circulate in the blood. Chronic naphthalene inhalation promotes lesions in the epithelium of the mouse lung and rat nose. Oral naphthalene exposure leads to DNA adduct formation in mouse lung, but the contributions of different enzymatic pathways and the metabolites they generate are not fully understood. This study explores the influence of naphthalene metabolites on DNA adduct formation in the lungs of two species (mice and primates). To isolate the lung response, conducting airway explants containing Club cells, a target for pulmonary naphthalene toxicity, were microdissected from live lung tissue and incubated with
Indexed as
DNA AdductsEnvironmental PollutantsLungNaphthalenesAnimalsCytochrome P-450 Enzyme SystemFemaleHumansMaleMiceMice, Inbred C57BLModels, AnimalNaphtholsNaphthoquinones1,2-dihydroxy-1,2-dihydronaphthalene1,2-naphthoquinoneCytochrome P-450 Enzyme SystemDNA AdductsEnvironmental PollutantsnaphthaleneNaphthalenesNaphtholsNaphthoquinones
Identifiers
PMID41730518
PMCPMC12997242
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390