Evidence map›Paper›PMID 41730104›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

The Nemp1-Nesprin complex mediates cellular responses to matrix mechanics.

Abira Ganguly, Hannah Zmuda, Javier Abello, Danielle Illy, Christopher Walter, Yonit Tsatskis, Nattapon Thanintorn, Ying Zhang, Bilal Ahmad Hakim, Didier Hodzic and 4 more

Erratum issuedAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Abira GangulyDepartment of Developmental Biology, Washington University, St. Louis, MO 63110.ORCID 0000-0003-1557-3146
Hannah ZmudaDepartment of Biomedical Engineering, Washington University, St. Louis, MO 63130-4899.
Javier AbelloDepartment of Cell Biology and Physiology, Washington University, St. Louis, MO 63110.
Danielle IllyDepartment of Developmental Biology, Washington University, St. Louis, MO 63110.
Christopher WalterDepartment of Biomedical Engineering, Washington University, St. Louis, MO 63130-4899.ORCID 0000-0003-3435-5558
Yonit TsatskisThe Cell Biology Program, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.ORCID 0000-0003-2580-0728
Nattapon ThanintornDepartment of Developmental Biology, Washington University, St. Louis, MO 63110.
Ying ZhangLunenfeld Tanenbaum Research Institute, Sinai Health System, Joseph & Wolf Lebovic Health Complex, Toronto, ON M5G 1X5, Canada.ORCID 0009-0007-1808-327X
Bilal Ahmad HakimDepartment of Developmental Biology, Washington University, St. Louis, MO 63110.ORCID 0009-0005-2794-3388
Didier HodzicDepartment of Developmental Biology, Washington University, St. Louis, MO 63110.
Amber N StratmanDepartment of Cell Biology and Physiology, Washington University, St. Louis, MO 63110.
Andrea JurisicovaLunenfeld Tanenbaum Research Institute, Sinai Health System, Joseph & Wolf Lebovic Health Complex, Toronto, ON M5G 1X5, Canada.
Amit PathakDepartment of Biomedical Engineering, Washington University, St. Louis, MO 63130-4899.ORCID 0000-0003-4006-5119
Helen McNeillDepartment of Developmental Biology, Washington University, St. Louis, MO 63110.ORCID 0000-0003-1126-5154

Funding

Dissecting the function of Nemp1, a nuclear envelope protein critical for mammalian fertilityR01HD108639 · NICHD · WASHINGTON UNIVERSITY · PI Helen McNeill · 2023 to 2026
$2.3M
HHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) RO1-HD10863NICHD NIH HHS R01 HD108639
6 · The paper itself

Abstract

Nuclear Envelope Membrane Protein 1 (NEMP1) is crucial for metazoan fertility; loss of Nemp1 causes death of primordial oocytes that reside in the mechanically challenging ovarian cortex. Here, we show that softening the ovary rescues oocyte loss and restores fertility in

Indexed as

Mechanotransduction, CellularMembrane ProteinsMicrofilament ProteinsNerve Tissue ProteinsNuclear ProteinsActin CytoskeletonActinsAnimalsCytoskeletal ProteinsFemaleHumansMiceMice, KnockoutOocytesOvaryYAP-Signaling ProteinsActinsCytoskeletal ProteinsMembrane ProteinsMicrofilament ProteinsNerve Tissue ProteinsNuclear ProteinsSyne1 protein, mouseYAP-Signaling Proteinscellular responses to mechanical stressKASH domainNemp1nuclear mechanotransductionYAP nuclear translocation

Identifiers

PMID41730104
PMCPMC12956887

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.