ArticlePLoS neglected tropical diseases2026
Comparative venomics reveals intra, interspecific and ontogenetic changes in the venom composition of Lachesis snakes from Colombia.
Article in PLoS neglected tropical diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn Colombia, Lachesis snakes are not commonly implicated in snakebite incidents. However, the considerable number of severe envenomation cases and associated mortality rates represent a significant challenge that must be overcome. A deeper comprehension of the composition of their venom, along with its variability across their distribution range, including ontogenetic and sexual variations, will contribute to the enhancement of the scarce knowledge about them and the mitigation of the consequences of snake envenomation. METHODOLOGY/PRINCIPAL
findingsThrough the application of snake venomics and in conjunction with biochemical characterization, here we analyze the venoms of fourteen specimens of Lachesis acrochorda (adults and juveniles) and L. muta from several geographical regions within Colombia. The venoms of juveniles and adults of L. acrochorda exhibited distinct chromatographic profiles and varying relative abundances of their toxins, indicating the presence of ontogenetic shifts, as well as enzymatic activities. Furthermore, a principal component analysis (PCA) revealed significant differences between the male and female samples in the chromatographic region associated with small peptides and nucleosides. In contrast, L. muta exhibited a relatively simple venom composition with low phospholipase activity and intense fibrinogen hydrolysis towards Aα and Bβ subunits. Finally, the Caldas sample exhibited the highest diversity of compounds and phospholipase activity.
conclusionsOverall, the results indicate that Lachesis venoms display compositional and functional variation, that depend on age, sex and geographical zone.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.