ArticlePloS one2026
Knowledge, attitudes, and practices of healthcare providers in Beijing regarding human immunodeficiency virus and tuberculosis co-infection: A multicenter cross-sectional study.
Article in PloS one, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundHuman Immunodeficiency Virus (HIV) and tuberculosis (TB) co-infection poses a significant challenge to public health systems due to its complex clinical management and high mortality. This study aimed to reveal the specific mechanisms through which knowledge influences practice in HIV/TB co-infection management among healthcare providers (HCPs) using structural equation modeling (SEM).
methodsAn exploratory cross-sectional study using convenience sampling was conducted from May to June 2025 involving healthcare providers (HCPs) across various medical institutions in Beijing, which included university-affiliated tertiary hospitals, specialized hospitals, and community health centers.
resultsA total of 565 valid questionnaires were collected, with 364 (64.42%) completed by medical doctors. The knowledge, attitude, and practice scores were 18.51 ± 7.75 (possible range: 0-30), 43.64 ± 5.51 (possible range: 10-50), and 30.75 ± 7.44 (possible range: 8-40), respectively. Spearman correlation analysis revealed significant positive correlations between knowledge and attitude (r = 0.500, P < 0.001), between attitude and practice (r = 0.584, P < 0.001) and between knowledge and practice (r = 0.592, P < 0.001). SEM analysis indicated that knowledge had a direct influence on both attitudes (β = 0.458, P = 0.002) and practices (β = 0.491, P = 0.011), while attitudes influenced practices (β = 0.272, P = 0.008). Furthermore, knowledge indirectly affected practices through attitudes (β = 0.124, P = 0.005).
conclusionIn our sample, respondents demonstrated limited knowledge, generally positive attitudes, and moderately adequate practices regarding HIV and TB co-infection. These preliminary findings suggest that targeted educational interventions designed to enhance knowledge may effectively improve both attitudes and practical behaviors, though more rigorous research is needed to confirm these relationships.
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