ArticleJournal of visualized experiments : JoVE2026
Multianimal Magnetic Resonance Imaging for Tumor Measurements in Pancreatic Cancer Mouse Models.
Article in Journal of visualized experiments : JoVE, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- The basal cell state maintains pancreatic cancers by controlling an immunosuppressive circuit.bioRxiv : the preprint server for biology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
Advanced in vivo imaging modalities, such as magnetic resonance imaging (MRI), are essential research tools to effectively detect tumors in preclinical mouse models. MRI provides detailed anatomical information on tumor location and size. However, this imaging modality is expensive and time-consuming. To overcome this access barrier without compromising imaging quality, a multianimal MRI protocol was implemented. This protocol uses a four-chamber bed insert to obtain high-resolution multianimal anatomical MRI scans within a single acquisition session. Simultaneously imagining multiple mice reduces the time and cost of this procedure. This protocol describes a multianimal MRI workflow designed to increase the efficiency of tumor detection and longitudinal tumor monitoring in a genetically engineered Kras-driven, p53-deleted (KPC) mouse model of pancreatic ductal adenocarcinoma. This well-established clinically relevant KPC model has provided invaluable insight into the molecular mechanisms underlying pancreatic carcinogenesis, tumor progression, and treatment resistance. As proof-of-concept, this protocol is applied to validate the therapeutic benefit of the standard-of-care chemotherapeutic agent gemcitabine in the KPC model. Future applications of this MRI-guided preclinical study design are briefly discussed to evaluate the therapeutic efficacy of combination therapies.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.