ReviewAnnual review of immunology2026
Cross-Organ Neuroimmunology of Behavior.
Review in Annual review of immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Here we introduce the Cross-Organ Neuroimmunology of Behavior (CONB) Network, a framework that reconceptualizes behavior as an emergent property of a distributed, whole-body immune-brain network. It builds on knowledge of neuroimmune communication, including cytokine modulation of neural activity and synaptic plasticity, neuroglial-immune interactions, and neuroendocrine pathways, forming a shared language for cross-organ signaling. We examine how peripheral organs function as network nodes, translating local immune or physiological changes into systemic signals that influence brain circuits and behavior. Integrating these axes reveals emergent network properties, such as redundant pathways (degeneracy) that enhance resilience and hub organs that exert disproportionate influence on network stability. This model links complex behavior to multisystem disease cross talk, reframing brain diseases as systemic network dysregulation. Ultimately, the CONB Network perspective informs precision medicine by leveraging immune biomarkers to identify patient subtypes and guide therapeutic strategies to recalibrate cross-organ neuroimmune networks and restore system-wide homeostasis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.