Evidence map›Paper›PMID 41729340›Full record

ArticleNeurochemical research2026

Targeting the Microbiota-Gut-Brain Axis: Bacillus coagulans Protects Against Rotenone-Induced Parkinson's Disease in Rats.

Monalisa Rout, Shakti Ketan Prusty, Vishal Singh, Sneha Kispotta, Prerana Sarangi, Durga Madhab Kar

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Article in Neurochemical research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Monalisa RoutSchool of Pharmaceutical Sciences-II, Siksha 'O' Anusandhan Deemed to Be University, Bhubaneswar, India.
Shakti Ketan PrustySchool of Pharmaceutical Sciences, Siksha 'O' Anusandhan Deemed to Be University, Bhubaneswar, India.
Vishal SinghSchool of Pharmaceutical Sciences, Siksha 'O' Anusandhan Deemed to Be University, Bhubaneswar, India.
Sneha KispottaSchool of Pharmaceutical Sciences, Siksha 'O' Anusandhan Deemed to Be University, Bhubaneswar, India.
Prerana SarangiSchool of Pharmaceutical Sciences, Siksha 'O' Anusandhan Deemed to Be University, Bhubaneswar, India.
Durga Madhab KarSchool of Pharmaceutical Sciences-II, Siksha 'O' Anusandhan Deemed to Be University, Bhubaneswar, India. durgamadhabkar@soa.ac.in.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gut microbiota and its derived metabolites affect brain physiology through several pathways. Dysfunction of gut-microbiota is involved in the pathogenesis of Parkinson's disease (PD). Introduced the pleiotropic effect of probiotics (PBT) in the function of the central nervous system, can delay the disease progression through microbiota-gut-brain axis (MGBA). PD is characterized by aggregated alpha-synuclein (α-syn), oxidative stress and neuroinflammation leading to depletion of dopaminergic neurons in the midbrain region. Our study designed to assess the neuroprotective effect of PBT Bacillus coagulans (B. coagulans) against rotenone (ROT) induced PD rats. To eliminate hormone-based errors associated with estrous cycle, we only used male rats in this experiment. ROT (50 mg/kg/day) caused perturbation of intestinal barrier leading to gut microbiome disturbances along with accumulation of α-syn in intestine and brain with motor deficits. qPCR of gut homogenate interpreted that treatment with B. coagulans alter the gut microbial composition in experimental PD through MGBA. This formulation claims as a supportive agent to restore the progression and aid in the therapeutic management of PD.

Indexed as

Bacillus coagulansBrainBrain-Gut AxisGastrointestinal MicrobiomeNeuroprotective AgentsParkinson Disease, SecondaryProbioticsalpha-SynucleinAnimalsMaleParkinson DiseaseRatsRats, WistarRotenonealpha-SynucleinNeuroprotective AgentsRotenoneB. coagulansGut-brain axisGut microbiotaParkinson’s diseaseProbiotics

Identifiers

PMID41729340

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.