Evidence map›Paper›PMID 41729328›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2026

Sirtuin1 modulates P53/Nrf2 pathway to promote spinal cord injury repair.

Xingxing Huang, Shengbo Shi, Zijing Zhang, Zetian Zhao, Junxiao Gao, Meng Zhang, Lu Qin, Xiaobing Yu

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Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xingxing HuangAffiliated Zhongshan Hospital of Dalian University, No. 6 Jiefang Street, Zhongshan District, Dalian, 116001, Liaoning Province, People's Republic of China.
Shengbo ShiAffiliated Zhongshan Hospital of Dalian University, No. 6 Jiefang Street, Zhongshan District, Dalian, 116001, Liaoning Province, People's Republic of China.
Zijing ZhangAffiliated Zhongshan Hospital of Dalian University, No. 6 Jiefang Street, Zhongshan District, Dalian, 116001, Liaoning Province, People's Republic of China.
Zetian ZhaoAffiliated Zhongshan Hospital of Dalian University, No. 6 Jiefang Street, Zhongshan District, Dalian, 116001, Liaoning Province, People's Republic of China.
Junxiao GaoAffiliated Zhongshan Hospital of Dalian University, No. 6 Jiefang Street, Zhongshan District, Dalian, 116001, Liaoning Province, People's Republic of China.
Meng ZhangAffiliated Zhongshan Hospital of Dalian University, No. 6 Jiefang Street, Zhongshan District, Dalian, 116001, Liaoning Province, People's Republic of China.
Lu QinAffiliated Zhongshan Hospital of Dalian University, No. 6 Jiefang Street, Zhongshan District, Dalian, 116001, Liaoning Province, People's Republic of China.ORCID http://orcid.org/0009-0000-1382-6459
Xiaobing YuAffiliated Zhongshan Hospital of Dalian University, No. 6 Jiefang Street, Zhongshan District, Dalian, 116001, Liaoning Province, People's Republic of China. yuxiaobing1976@hotmail.com.ORCID http://orcid.org/0000-0002-3811-8608

Funding

Dalian Science and Technology Innovation Fund 2021JJ13SN68
6 · The paper itself

Abstract

objectiveSpinal cord injury (SCI) is characterized by its high incidence, high disability rate, and high treatment costs, making the development of effective therapeutic strategies a major focus. Secondary injury mechanisms in SCI involve complex processes such as inflammation, oxidative stress, and apoptosis, which are critical to patient prognosis.

methodsThis study investigates the role of SIRT1 in SCI repair, particularly its molecular mechanisms in regulating the P53/Nrf2 signaling pathway. By constructing a recombinant adenovirus overexpressing SIRT1 and conducting both in vitro and in vivo validation, we found that SIRT1 modulates the P53/Nrf2 pathway by downregulating P53 and upregulating Nrf2 expression, significantly inhibiting the expression of inflammatory factors TNF-α, IL-1β, and IL-6, while increasing the expression of the anti-inflammatory factor IL-10. Additionally, SIRT1 reduced apoptosis by regulating Bax and Bcl-2 expression, and enhanced cellular antioxidant capacity through activation of Nrf2. These regulatory effects significantly promoted motor function recovery in SCI rats.

conclusionThis study provides mechanistic evidence for the neuroprotective role of SIRT1 in SCI and establishes a foundation for considering SIRT1 as a novel therapeutic target for SCI.

Indexed as

NF-E2-Related Factor 2Signal TransductionSirtuin 1Spinal Cord InjuriesTumor Suppressor Protein p53AnimalsApoptosisCytokinesDisease Models, AnimalMaleRatsRats, Sprague-DawleyRecovery of FunctionCytokinesNfe2l2 protein, ratNF-E2-Related Factor 2Sirt1 protein, ratSirtuin 1Tp53 protein, ratTumor Suppressor Protein p53Gene therapyp53/Nrf2 signaling pathwayRepair of injurySirtuin1Spinal cord injury

Identifiers

PMID41729328

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.