ReviewBiotechnology letters2026
Advances in genome-scale metabolic modeling of Bacillus subtilis.
Review in Biotechnology letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
1 author.
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Abstract
Bacillus subtilis is a key industrial microorganism widely used to produce enzymes, vitamins, antibiotics, and recombinant proteins. Its non-pathogenic nature, efficient protein secretion systems, and genetic tractability make it an ideal candidate for industrial biotechnology. Genome-scale metabolic modeling has emerged as a key systems biology approach to understand, explore and manipulate the metabolism of B. subtilis for improved strain performance. To date, the modeling efforts have resulted in fourteen published genome-scale metabolic reconstructions for B. subtilis; however, substantial opportunities for improvement remain, especially in integrating regulatory mechanisms for refining model accuracy. Furthermore, there is a growing trend toward modelling the cell as a whole system. This article is the first comprehensive and up-to-date review that highlights the genome sequencing, annotation efforts and the current state of genome-scale metabolic modeling for B. subtilis, emphasizing future directions.
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Registered trials
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