Evidence map›Paper›PMID 41729241›Full record

ArticleAnalytical and bioanalytical chemistry2026

Tyndall-effect-based colorimetric enzyme-linked aptamer assay for instrument-free thrombin detection via enzyme-triggered degradation of MnO

Jiale Hu, Wei Li, Pei Luo, Yihong Nan, Yimin Liu, Yashi Yang, Jianmei Zou, Huijun He, Yun Zhang

Abstract readEvaluation Study
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In one paragraph

Article in Analytical and bioanalytical chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jiale HuGuangxi Key Laboratory of Electrochemical and Magnetochemical Function Materials, Guilin University of Technology, 12 Jiangan Road, Guilin, 541004, China.
Wei LiGuangxi Key Laboratory of Electrochemical and Magnetochemical Function Materials, Guilin University of Technology, 12 Jiangan Road, Guilin, 541004, China.
Pei LuoGuangxi Key Laboratory of Electrochemical and Magnetochemical Function Materials, Guilin University of Technology, 12 Jiangan Road, Guilin, 541004, China.
Yihong NanGuangxi Key Laboratory of Electrochemical and Magnetochemical Function Materials, Guilin University of Technology, 12 Jiangan Road, Guilin, 541004, China.
Yimin LiuGuangxi Key Laboratory of Electrochemical and Magnetochemical Function Materials, Guilin University of Technology, 12 Jiangan Road, Guilin, 541004, China.
Yashi YangGuangxi Key Laboratory of Electrochemical and Magnetochemical Function Materials, Guilin University of Technology, 12 Jiangan Road, Guilin, 541004, China.
Jianmei ZouGuangxi Key Laboratory of Electrochemical and Magnetochemical Function Materials, Guilin University of Technology, 12 Jiangan Road, Guilin, 541004, China. 2019136@glut.edu.cn.
Huijun HeGuangxi Key Laboratory of Environmental Pollution Control Theory and Technology, Guilin University of Technology, Guilin, 541006, China.
Yun ZhangGuangxi Key Laboratory of Electrochemical and Magnetochemical Function Materials, Guilin University of Technology, 12 Jiangan Road, Guilin, 541004, China.

Funding

National Natural Science Foundation of China 22264011Natural Science Foundation of Guangxi Zhuang Autonomous Region 2020GXNSFBA297114
6 · The paper itself

Abstract

In this work, an innovative Tyndall-effect-based (TE-based) colorimetric strategy was developed to detect the activity of alkaline phosphatase (ALP) via enzyme-triggered degradation of MnO₂ nanosheets (MnO₂ NSs), and it was further extended to construct a TE-based colorimetric enzyme-linked aptamer assay (ELAA) for monitoring thrombin (TB) concentrations. In the presence of ALP, ascorbic acid 2-phosphate (AAP) was hydrolyzed to ascorbic acid (AA), which in turn reduced MnO₂ NSs to Mn

Indexed as

Alkaline PhosphataseAptamers, NucleotideBiosensing TechniquesColorimetryManganese CompoundsNanostructuresOxidesThrombinHumansLimit of DetectionAlkaline PhosphataseAptamers, NucleotideManganese Compoundsmanganese dioxideOxidesThrombinEnzyme-linked aptamer assayInstrument-free readoutMnO₂ nanosheetProtein analysisTyndall effect

Identifiers

PMID41729241

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.