Evidence map›Paper›PMID 41729211›Full record

ArticleJournal of molecular histology2026

The IGF2BP3/SLC2A1 axis mediates hsa_circ_0000376-Induced malignant progression and neutrophil N2 polarization in the lung adenocarcinoma microenvironment.

ZhiBin Lu, Yi Chen, ZhiChao Xiao, SiDong He, YinPing Huo, Hui Sun, Qiang Cai

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of molecular histology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

ZhiBin Lu *Department of Cardiothoracic Surgery, Nanjing Pukou People's Hospital, Liangjiang Hospital, Southeast University, Pukou People's Hospital Affiliated to Jiangsu Health Vocational College, No. 166, Shanghe Street, Pukou District, Nanjing City, 211899, Jiangsu Province, China.
Yi Chen *Department of Oncology, Nanjing Pukou People's Hospital, Liangjiang Hospital， Southeast University, Pukou People's Hospital Affiliated to Jiangsu Health Vocational College, No. 166, Shanghe Street, Pukou District, Nanjing City, 211899, Jiangsu Province, China.
ZhiChao XiaoDepartment of Cardiothoracic Surgery, Nanjing Pukou People's Hospital, Liangjiang Hospital, Southeast University, Pukou People's Hospital Affiliated to Jiangsu Health Vocational College, No. 166, Shanghe Street, Pukou District, Nanjing City, 211899, Jiangsu Province, China.
SiDong HeDepartment of Cardiothoracic Surgery, Nanjing Pukou People's Hospital, Liangjiang Hospital, Southeast University, Pukou People's Hospital Affiliated to Jiangsu Health Vocational College, No. 166, Shanghe Street, Pukou District, Nanjing City, 211899, Jiangsu Province, China.
YinPing HuoDepartment of Respiratory and Critical Care Medicine, Nanjing Pukou People's Hospital, Liangjiang Hospital, Southeast University, Pukou People's Hospital Affiliated to Jiangsu Health Vocational College, Nanjing City, 211899, Jiangsu Province, China.
Hui SunDepartment of Oncology, Nanjing Pukou People's Hospital, Liangjiang Hospital， Southeast University, Pukou People's Hospital Affiliated to Jiangsu Health Vocational College, No. 166, Shanghe Street, Pukou District, Nanjing City, 211899, Jiangsu Province, China. sh13912922843@sina.com.
Qiang CaiDepartment of Cardiothoracic Surgery, Nanjing Pukou People's Hospital, Liangjiang Hospital, Southeast University, Pukou People's Hospital Affiliated to Jiangsu Health Vocational College, No. 166, Shanghe Street, Pukou District, Nanjing City, 211899, Jiangsu Province, China. 13851640471@163.com.

Funding

Key Project of the "Medicine-Education Coordination & Integrated Chinese-Western Medicine" Special Initiative, Jiangsu Health Vocational College 1.Grant No. YJXT-PR202404Medical Research Project of Jiangsu Provincial Health Commission Grant No. ZQ2024022
6 · The paper itself

Abstract

Lung adenocarcinoma (LUAD) is an exceptionally aggressive malignancy characterized by high mortality rates. Neutrophils fulfill dual roles in cancer, demonstrating the capacity to both inhibit and facilitate tumor development. This study aimed to delineate the functional contributions and mechanistic underpinnings of Homo sapiens circular RNA 0000376 (hsa_circ_0000376) in LUAD progression and neutrophil polarization. Quantitative real-time polymerase chain reaction (RT-qPCR) was utilized to determine the expression levels of hsa_circ_0000376 in LUAD clinical specimens and established cell lines. A comprehensive set of experimental techniques was applied to evaluate its influence on LUAD cellular phenotypes: the Cell Counting Kit-8 (CCK-8) assay for assessing proliferation, colony formation assay for clonogenic potential, flow cytometry for detecting apoptosis, the scratch wound assay for evaluating migration, and the Transwell assay for quantifying invasive capacity. Flow cytometric analysis was additionally employed to measure neutrophil polarization towards the N1 (inducible nitric oxide synthase [iNOS]

Indexed as

Adenocarcinoma of LungGlucose Transporter Type 1Lung NeoplasmsNeutrophilsRNA-Binding ProteinsRNA, CircularTumor MicroenvironmentApoptosisCell Line, TumorCell MovementCell PolarityCell ProliferationDisease ProgressionFemaleGene Expression Regulation, NeoplasticHumansGlucose Transporter Type 1IGF2BP3 protein, humanRNA-Binding ProteinsRNA, CircularSLC2A1 protein, humanHsa_circ_0000376IGF2BP3LUADNeutrophil N2 polarizationProliferationSLC2A1

Identifiers

PMID41729211

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.