Evidence map›Paper›PMID 41729176›Full record

ArticleVeterinary medicine and science2026

Genome-Wide Association Study of Leukocyte Traits Reveals Candidate Genes Associated With Immunity in Holstein Cattle From Southern China.

Chenhui Liu, Jie Yu, Zhuxia Zhong, Xiuzhong Hu, Min Xiang, Xiaoyong Du, Mohammad Abdul Latif, Wenxuan Wang, Liangyu Shi, Hongbo Chen and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Veterinary medicine and science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Chenhui LiuInstitute of Animal Science and Veterinary Medicine, Wuhan Academy of Agricultural Sciences, Wuhan, Hubei, China.ORCID https://orcid.org/0000-0003-0942-4662
Jie YuInstitute of Animal Science and Veterinary Medicine, Wuhan Academy of Agricultural Sciences, Wuhan, Hubei, China.ORCID https://orcid.org/0009-0009-9873-3002
Zhuxia ZhongInstitute of Animal Science and Veterinary Medicine, Wuhan Academy of Agricultural Sciences, Wuhan, Hubei, China.
Xiuzhong HuInstitute of Animal Science and Veterinary Medicine, Wuhan Academy of Agricultural Sciences, Wuhan, Hubei, China.ORCID https://orcid.org/0009-0008-0120-6824
Min XiangInstitute of Animal Science and Veterinary Medicine, Wuhan Academy of Agricultural Sciences, Wuhan, Hubei, China.
Xiaoyong DuKey Laboratory of Smart Animal Farming Technology, Ministry of Agriculture, College of Informatics, Huazhong Agricultural University, Wuhan, Hubei, China.ORCID https://orcid.org/0000-0002-0892-1993
Mohammad Abdul LatifKey Laboratory of Smart Animal Farming Technology, Ministry of Agriculture, College of Informatics, Huazhong Agricultural University, Wuhan, Hubei, China.
Wenxuan WangKey Laboratory of Smart Animal Farming Technology, Ministry of Agriculture, College of Informatics, Huazhong Agricultural University, Wuhan, Hubei, China.ORCID https://orcid.org/0009-0008-4995-0628
Liangyu ShiHubei Provincial Center of Technology Innovation for Domestic Animal Breeding, Wuhan Polytechnic University, Wuhan, Hubei, China.ORCID https://orcid.org/0000-0003-4236-3531
Hongbo ChenHubei Provincial Center of Technology Innovation for Domestic Animal Breeding, Wuhan Polytechnic University, Wuhan, Hubei, China.ORCID https://orcid.org/0000-0002-6051-3321
Lei ChengInstitute of Animal Science and Veterinary Medicine, Wuhan Academy of Agricultural Sciences, Wuhan, Hubei, China.ORCID https://orcid.org/0000-0002-3857-6019

Funding

Hubei Provincial Natural Science Foundation 2022CFB913Hubei Provincial Technology Innovation Plan Project 2023BBB058IAEA CRP project CRPD31028IAEA CRP project CRPD31030
6 · The paper itself

Abstract

Leukocyte traits are crucial clinical indicators for various diseases, reflecting the immunity in dairy cows and indicating production performance and elimination rate. In Southern China, diseases caused by high temperature and humidity in summer significantly impact the production of dairy cows. Conducting a genome-wide association study (GWAS) on leukocyte counts and components in healthy individuals is essential for identifying genes involved in leukocyte production, differentiation or clearance, thereby aiding in the accurate identification of genetic sources of immune variation in dairy cows. This study measured leukocyte traits in 200 healthy dairy cows and conducted GWAS. The results revealed 70 single-nucleotide polymorphisms (SNPs). Of these, 15 SNPs were within genes and all in introns. Additionally, the BEN Domain-Containing Protein 5 (BEND5) gene, which regulates white blood cell count (WBC), percentage of basophils (%BASO) and percentage of lymphocytes (%LYMPH), and the Forkhead box J3 (FOXJ3) gene, which regulates WBC and %BASO, were identified as two crucial candidate genes. This study provides new evidence on the genetic basis of immunity differences in dairy cows in Southern China, suggesting that the SNPs and candidate genes identified could be valuable for dairy cow breeding.

Indexed as

Genome-Wide Association StudyLeukocytesPolymorphism, Single NucleotideAnimalsCattleChinaFemaleLeukocyte Countcandidate genedairy cowsgenome‐wide associationleukocyte traitssingle‐nucleotide polymorphism (SNP)

Identifiers

PMID41729176
PMCPMC12927994

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.