ArticleSkin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)2026
Comparative Evaluation of Topical Stabilized Retinaldehyde 0.1% vs. 0.05% on Skin Biophysical and Biomechanical Parameters.
Article in Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07510165 (Multimodal Assessment of Structural and Spectral Changes in Aging Skin Induced by Topical Application of Stabilized Retinaldehyde at 0.1% and 0.05%), which is not on this map. Not yet cited in PubMed.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Multimodal Assessment of Structural and Spectral Changes in Aging Skin Induced by Topical Application of Stabilized Retinaldehyde at 0.1% and 0.05%: A 24-Week Split-Face Study
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9 authors.
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Abstract
backgroundThe aim of this study was to evaluate the biophysical and biomechanical effects of topical stabilized retinaldehyde (RAL) treatments on skin, using different concentrations of retinal (0.05% and 0.1%). MATERIALS AND
methodsEmploying a split-face design and noninvasive methods such as high-frequency ultrasonography, the Antera 3D camera, and the Cutometer, the effectiveness of these preparations was assessed among 56 women aged 30-58 years.
resultsThe application of topical stabilized RAL resulted in statistically significant improvements in skin parameters. High-frequency ultrasonography revealed increased dermal density across all facial regions after 24 weeks, while Cutometer measurements showed enhanced skin elasticity and viscoelasticity. Antera 3D imaging demonstrated significant reductions in wrinkle parameters, particularly with the higher concentration (0.1%) of RAL. The treatments were generally well-tolerated, with minimal adverse effects reported, highlighting their suitability for sensitive skin.
conclusionResults indicated significant improvements in skin texture and firmness, particularly with the higher 0.1% concentration of RAL over 24-week period, making it a promising option for long-term skin rejuvenation therapy.
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